P2X7 mediates loss of intracellular K+

Stable Identifier
R-HSA-877187
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Low level or transient activation of P2X7 leads to reversible opening of a membrane channel permeable to small cations such as Na+, Ca2+ and K+ (Adinolfi et al. 2005).

Literature References
PubMed ID Title Journal Year
9023774 Purinoceptor-operated cationic channels in human B lymphocytes

Markwardt, F, Lohn, M, Bohm, T, Klapperstuck, M

J Physiol 1997
11157473 Nucleotide receptors: an emerging family of regulatory molecules in blood cells

Di Virgilio, F, Chiozzi, P, Ferrari, D, Falzoni, S, Sanz, JM, Morelli, A, Torboli, M, Bolognesi, G, Baricordi, OR

Blood 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
extracellularly ATP-gated cation channel activity of ATP:P2X7 oligomer [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created