P2X7 mediates loss of intracellular K+

Stable Identifier
R-HSA-877187
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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P2X7 mediates loss of intracellular K+
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Low level or transient activation of P2X7 leads to reversible opening of a membrane channel permeable to small cations such as Na+, Ca2+ and K+ (Adinolfi et al. 2005).
Literature References
PubMed ID Title Journal Year
11157473 Nucleotide receptors: an emerging family of regulatory molecules in blood cells

Di Virgilio, F, Chiozzi, P, Ferrari, D, Falzoni, S, Sanz, JM, Morelli, A, Torboli, M, Bolognesi, G, Baricordi, OR

Blood 2001
9023774 Purinoceptor-operated cationic channels in human B lymphocytes

Markwardt, F, Lohn, M, Bohm, T, Klapperstuck, M

J Physiol 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

extracellularly ATP-gated monoatomic cation channel activity of ATP:P2X7 oligomer [plasma membrane]

Physical Entity
ATP:P2X7 oligomer [plasma membrane] (Homo sapiens)
Activity
extracellularly ATP-gated monoatomic cation channel activity (GO:0004931)
Orthologous Events
P2X7 mediates loss of intracellular K+ (Bos taurus)
P2X7 mediates loss of intracellular K+ (Canis familiaris)
P2X7 mediates loss of intracellular K+ (Danio rerio)
P2X7 mediates loss of intracellular K+ (Dictyostelium discoideum)
P2X7 mediates loss of intracellular K+ (Gallus gallus)
P2X7 mediates loss of intracellular K+ (Mus musculus)
P2X7 mediates loss of intracellular K+ (Rattus norvegicus)
P2X7 mediates loss of intracellular K+ (Sus scrofa)
Cross References
Rhea
Authored
Jupe, S  (2010-04-22)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2010-06-11)
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