Binding of STAT1 to p-IFNGR1

Stable Identifier
R-HSA-873921
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Binding of STAT1 to p-IFNGR1
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The phosphorylated tyrosine residue 440 in the 440YDKPH444 motif on IFNGR1 chain serves as a docking site and recruits STAT1, an SH2 domain-containing transcription factor to the functional receptor unit.
Literature References
PubMed ID Title Journal Year
8156998 Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)

Greenlund, AC, Schreiber, RD, Viviano, BL, Farrar, MA

EMBO J 1994
7796299 Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process

Krolewski, J, Morales, MO, Greenlund, AC, Yan, H, Schreiber, RD, Viviano, BL

Immunity 1995
12040185 A road map for those who don't know JAK-STAT

Horvath, CM, Aaronson, DS

Science 2002
Participants
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Output
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as an event of
Orthologous Events
Binding of STAT1 to p-IFNGR1 (Bos taurus)
Binding of STAT1 to p-IFNGR1 (Canis familiaris)
Binding of STAT1 to p-IFNGR1 (Danio rerio)
Binding of STAT1 to p-IFNGR1 (Gallus gallus)
Binding of STAT1 to p-IFNGR1 (Mus musculus)
Binding of STAT1 to p-IFNGR1 (Rattus norvegicus)
Binding of STAT1 to p-IFNGR1 (Sus scrofa)
Authored
Garapati, P V  (2010-06-08)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-06-08)
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