Reactome | Binding of STAT1 to p-IFNGR1

Binding of STAT1 to p-IFNGR1

Stable Identifier

R-HSA-873921

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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The phosphorylated tyrosine residue 440 in the 440YDKPH444 motif on IFNGR1 chain serves as a docking site and recruits STAT1, an SH2 domain-containing transcription factor to the functional receptor unit.

Literature References

PubMed ID	Title	Journal	Year
7796299	Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process Greenlund, AC, Morales, MO, Viviano, BL, Yan, H, Krolewski, J, Schreiber, RD	Immunity	1995
8156998	Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91) Greenlund, AC, Farrar, MA, Viviano, BL, Schreiber, RD	EMBO J	1994
12040185	A road map for those who don't know JAK-STAT Aaronson, DS, Horvath, CM	Science	2002