Reactome | Binding of STAT1 to p-IFNGR1

Binding of STAT1 to p-IFNGR1

Stable Identifier

R-HSA-873921

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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The phosphorylated tyrosine residue 440 in the 440YDKPH444 motif on IFNGR1 chain serves as a docking site and recruits STAT1, an SH2 domain-containing transcription factor to the functional receptor unit.

Literature References

PubMed ID	Title	Journal	Year
8156998	Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91) Greenlund, AC, Schreiber, RD, Viviano, BL, Farrar, MA	EMBO J	1994
7796299	Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process Krolewski, J, Morales, MO, Greenlund, AC, Yan, H, Schreiber, RD, Viviano, BL	Immunity	1995
12040185	A road map for those who don't know JAK-STAT Horvath, CM, Aaronson, DS	Science	2002