Binding of STAT1 to p-IFNGR1

Stable Identifier
R-HSA-873921
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The phosphorylated tyrosine residue 440 in the 440YDKPH444 motif on IFNGR1 chain serves as a docking site and recruits STAT1, an SH2 domain-containing transcription factor to the functional receptor unit.

Literature References
PubMed ID Title Journal Year
7796299 Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process

Greenlund, AC, Morales, MO, Viviano, BL, Yan, H, Krolewski, J, Schreiber, RD

Immunity 1995
8156998 Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)

Greenlund, AC, Farrar, MA, Viviano, BL, Schreiber, RD

EMBO J 1994
12040185 A road map for those who don't know JAK-STAT

Aaronson, DS, Horvath, CM

Science 2002
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!