Reactome | SGT1:HSP90 binds inactive NLRP3

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SGT1:HSP90 binds inactive NLRP3 Show undefined attributes

authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:874056] Jupe, S, 2010-06-09
dbId	873951
displayName	SGT1:HSP90 binds inactive NLRP3
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
eventOf	[Pathway:R-HSA-844456] The NLRP3 inflammasome - Homo sapiens [Pathway:R-HSA-9660826] Purinergic signaling in leishmaniasis infection - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1306876] NLRP3 activation by small molecules - Homo sapiens [BlackBoxEvent:R-HSA-844440] NLRP3 activation by elicitor proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-561189] NLRP3 [cytosol] [Complex:R-HSA-874112] SUGT1:HSP90 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:874000] A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses [LiteratureReference:9706709] Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SGT1:HSP90 binds inactive NLRP3
orthologousEvent	[Reaction:R-GGA-873951] SGT1:HSP90 binds inactive NLRP3 - Gallus gallus [Reaction:R-XTR-873951] SGT1:HSP90 binds inactive NLRP3 - Xenopus tropicalis [Reaction:R-DRE-873951] SGT1:HSP90 binds inactive NLRP3 - Danio rerio [Reaction:R-SSC-873951] SGT1:HSP90 binds inactive NLRP3 - Sus scrofa [Reaction:R-BTA-873951] SGT1:HSP90 binds inactive NLRP3 - Bos taurus [Reaction:R-CFA-873951] SGT1:HSP90 binds inactive NLRP3 - Canis familiaris [Reaction:R-RNO-873951] SGT1:HSP90 binds inactive NLRP3 - Rattus norvegicus [Reaction:R-MMU-873951] SGT1:HSP90 binds inactive NLRP3 - Mus musculus
output	[Complex:R-HSA-874086] NLRP3:SUGT1:HSP90 [cytosol]
precedingEvent	[Reaction:R-HSA-874087] SGT1 binds HSP90 - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-873951
summation	[Summation:874021] SGT1 and HSP90 bind the NLRP3 (NALP3) LRR domain. Genetic s...
updateTrackers	[UpdateTracker:9776629] Update Tracker - [Reaction:873951] SGT1:HSP90 binds inactive NLRP3 - v75:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776629] Update Tracker - [Reaction:873951] SGT1:HSP90 binds inactive NLRP3 - v75:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9660826] Purinergic signaling in leishmaniasis infection [Pathway:R-HSA-844456] The NLRP3 inflammasome
(precedingEvent)	[BlackBoxEvent:R-HSA-1306876] NLRP3 activation by small molecules [BlackBoxEvent:R-HSA-844440] NLRP3 activation by elicitor proteins