Reactome | P2X7 mediates membrane pores that include pannexin-1

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P2X7 mediates membrane pores that include pannexin-1 Show undefined attributes

authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
category	uncertain
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:877211] Jupe, S, 2010-06-11
dbId	877198
displayName	P2X7 mediates membrane pores that include pannexin-1
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
eventOf	[Pathway:R-HSA-844456] The NLRP3 inflammasome - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-844440] NLRP3 activation by elicitor proteins - Homo sapiens [BlackBoxEvent:R-HSA-1306876] NLRP3 activation by small molecules - Homo sapiens
input	[Complex:R-HSA-877257] ATP:P2X7 oligomer [plasma membrane] [Complex:R-HSA-9855178] PANX1 heptamer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:877222] ATP induces nucleotide permeability in rat mast cells [LiteratureReference:877251] ATP-induced pore formation in the plasma membrane of rat peritoneal mast cells [LiteratureReference:874011] Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor [LiteratureReference:9892586] P2X7 receptor-Pannexin1 complex: pharmacology and signaling
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	P2X7 mediates membrane pores that include pannexin-1
orthologousEvent	[BlackBoxEvent:R-GGA-877198] P2X7 mediates membrane pores that include pannexin-1 - Gallus gallus [BlackBoxEvent:R-XTR-877198] P2X7 mediates membrane pores that include pannexin-1 - Xenopus tropicalis [BlackBoxEvent:R-DRE-877198] P2X7 mediates membrane pores that include pannexin-1 - Danio rerio [BlackBoxEvent:R-SSC-877198] P2X7 mediates membrane pores that include pannexin-1 - Sus scrofa [BlackBoxEvent:R-BTA-877198] P2X7 mediates membrane pores that include pannexin-1 - Bos taurus [BlackBoxEvent:R-CFA-877198] P2X7 mediates membrane pores that include pannexin-1 - Canis familiaris [BlackBoxEvent:R-RNO-877198] P2X7 mediates membrane pores that include pannexin-1 - Rattus norvegicus [BlackBoxEvent:R-MMU-877198] P2X7 mediates membrane pores that include pannexin-1 - Mus musculus
output	[Complex:R-HSA-877242] ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane]
precedingEvent	[Reaction:R-HSA-877158] P2X7 forms oligomeric non-selective cation channels - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06 [InstanceEdit:9910908] May, Bruce, 2024-05-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-877198
summation	[Summation:877185] At higher concentrations of extracellular ATP, the P2X7 chan...
updateTrackers	[UpdateTracker:9911008] Update Tracker - [BlackBoxEvent:877198] P2X7 mediates membrane pores that include pannexin-1 - v89:[addLiteratureReference, add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9911008] Update Tracker - [BlackBoxEvent:877198] P2X7 mediates membrane pores that include pannexin-1 - v89:[addLiteratureReference, add_removeInput]
(precedingEvent)	[BlackBoxEvent:R-HSA-1306876] NLRP3 activation by small molecules [BlackBoxEvent:R-HSA-844440] NLRP3 activation by elicitor proteins
(hasEvent)	[Pathway:R-HSA-844456] The NLRP3 inflammasome