Reactome | TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1

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TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 Show undefined attributes

category	dissociation
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:110071] Tschopp, J�rg, 2004-01-28
dbId	83582
displayName	TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1
edited	[InstanceEdit:3508822] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-5357786] TNFR1-induced proapoptotic signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9819106] ULK1 phosphorylates RIPK1 at S357 - Homo sapiens [Reaction:R-HSA-9815501] MAPKAPK2 phosphorylates RIPK1 at S320 - Homo sapiens [Reaction:R-HSA-140978] TRADD:TRAF2:RIP1 binds FADD - Homo sapiens
input	[Complex:R-HSA-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140979] Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes [LiteratureReference:3465531] Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1
orthologousEvent	[Reaction:R-DRE-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Danio rerio [Reaction:R-SSC-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Sus scrofa [Reaction:R-BTA-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Bos taurus [Reaction:R-CFA-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Canis familiaris [Reaction:R-RNO-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Rattus norvegicus [Reaction:R-MMU-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Mus musculus
output	[DefinedSet:R-HSA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] [Complex:R-HSA-140935] TRAF2:TRADD:RIPK1 [cytosol]
precedingEvent	[Reaction:R-HSA-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Homo sapiens
regulatedBy	[NegativeRegulation:9820383] Negative regulation by 'TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane]' [NegativeRegulation:9820391] Negative regulation by 'TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]'
regulationReference	[RegulationReference:9820378] Negative regulation by 'TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane]' Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential [RegulationReference:9820395] Negative regulation by 'TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]' TBK1 and IKK? prevent TNF-induced cell death by RIPK1 phosphorylation
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165094] Vaux, D, 0000-00-00 00:00:00 [InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25 [InstanceEdit:9818965] Tu, Hailin, 2022-10-31
revised	[InstanceEdit:3604387] Shamovsky, V, 2013-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-83582
summation	[Summation:74353] Once formed in context of the TNFR1 signaling complex the TR...
updateTrackers	[UpdateTracker:9846850] Update Tracker - [Reaction:83582] TRADD:TRAF2:RIP1 complex dissociates from the TNF-?:TNF-R1 complex. - v83:[addRegulator] [UpdateTracker:9784656] Update Tracker - [Reaction:83582] TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. - v53:[modifyText] [UpdateTracker:9787358] Update Tracker - [Reaction:83582] TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. - v45:[addLiteratureReference, add_removeOutput] [UpdateTracker:9785057] Update Tracker - [Reaction:83582] TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. - v52:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9846850] Update Tracker - [Reaction:83582] TRADD:TRAF2:RIP1 complex dissociates from the TNF-?:TNF-R1 complex. - v83:[addRegulator] [UpdateTracker:9784656] Update Tracker - [Reaction:83582] TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. - v53:[modifyText] [UpdateTracker:9787358] Update Tracker - [Reaction:83582] TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. - v45:[addLiteratureReference, add_removeOutput] [UpdateTracker:9785057] Update Tracker - [Reaction:83582] TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. - v52:[modifyText]
(hasEvent)	[Pathway:R-HSA-5357786] TNFR1-induced proapoptotic signaling
(precedingEvent)	[Reaction:R-HSA-9819106] ULK1 phosphorylates RIPK1 at S357 [Reaction:R-HSA-9815501] MAPKAPK2 phosphorylates RIPK1 at S320 [Reaction:R-HSA-140978] TRADD:TRAF2:RIP1 binds FADD

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