Reactome | Coumarin is 7-hydroxylated by CYP2A6

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Coumarin is 7-hydroxylated by CYP2A6 Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:76451] coumarin 7-hydroxylase activity of Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen [Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
dbId	76453
displayName	Coumarin is 7-hydroxylated by CYP2A6
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-211981] Xenobiotics - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5335] coumarin metabolic process
input	[SimpleEntity:R-ALL-76328] COUM [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:211806] Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Coumarin is 7-hydroxylated by CYP2A6
orthologousEvent	[Reaction:R-DDI-76453] Coumarin is 7-hydroxylated by CYP2A6 - Dictyostelium discoideum [Reaction:R-CEL-76453] Coumarin is 7-hydroxylated by CYP2A6 - Caenorhabditis elegans [Reaction:R-XTR-76453] Coumarin is 7-hydroxylated by CYP2A6 - Xenopus tropicalis [Reaction:R-DRE-76453] Coumarin is 7-hydroxylated by CYP2A6 - Danio rerio [Reaction:R-SSC-76453] Coumarin is 7-hydroxylated by CYP2A6 - Sus scrofa [Reaction:R-BTA-76453] Coumarin is 7-hydroxylated by CYP2A6 - Bos taurus [Reaction:R-CFA-76453] Coumarin is 7-hydroxylated by CYP2A6 - Canis familiaris [Reaction:R-RNO-76453] Coumarin is 7-hydroxylated by CYP2A6 - Rattus norvegicus [Reaction:R-MMU-76453] Coumarin is 7-hydroxylated by CYP2A6 - Mus musculus
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-76452] HCOU [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-76453
summation	[Summation:178560] The 7-hydroxylation of coumarin is used as an assay of P450 ...
updateTrackers	[UpdateTracker:9791937] Update Tracker - [Reaction:76453] Coumarin is 7-hydroxylated by CYP2A6 - v24:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791937] Update Tracker - [Reaction:76453] Coumarin is 7-hydroxylated by CYP2A6 - v24:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-211981] Xenobiotics