Reactome | Xenobiotics

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Xenobiotics Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:211969] Jassal, B, 2008-02-08 15:33:52
dbId	211981
displayName	Xenobiotics
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-211897] Cytochrome P450 - arranged by substrate type - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-76472] Ethylene is oxidized to Ethylene oxide by CYP1A1 - Homo sapiens [Pathway:R-HSA-211957] Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 - Homo sapiens [Reaction:R-HSA-76453] Coumarin is 7-hydroxylated by CYP2A6 - Homo sapiens [Reaction:R-HSA-211881] Coumarin is 7-hydroxylated by CYP2A13 - Homo sapiens [Reaction:R-HSA-211991] Cyclophosphamide is 4-hydroxylated by CYP2B6 - Homo sapiens [Reaction:R-HSA-211910] CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation - Homo sapiens [Reaction:R-HSA-211988] CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation - Homo sapiens [Reaction:R-HSA-212004] CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation - Homo sapiens [Reaction:R-HSA-211929] CYP2C19 5-hydroxylates omeprazole - Homo sapiens [Pathway:R-HSA-211999] CYP2E1 reactions - Homo sapiens [Reaction:R-HSA-76456] O-atom dealkylation of dextromethorphan - Homo sapiens [Reaction:R-HSA-211966] CYP2D6 4-hydroxylates debrisoquine - Homo sapiens [Reaction:R-HSA-212005] CYP2F1 dehydrogenates 3-methylindole - Homo sapiens [Reaction:R-HSA-211948] CYP3A4 can N-demethylate loperamide - Homo sapiens [Reaction:R-HSA-213175] CYP3A4,5 oxidise AFB1 to AFXBO - Homo sapiens [Reaction:R-HSA-211882] CYP3A7 can 6beta-hydroxylate testosterone - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:266185] 57 varieties: the human cytochromes P450 [LiteratureReference:266174] Cytochrome P450s and other enzymes in drug metabolism and toxicity [LiteratureReference:266241] The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
maxDepth	3
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Xenobiotics
orthologousEvent	[Pathway:R-DDI-211981] Xenobiotics - Dictyostelium discoideum [Pathway:R-CEL-211981] Xenobiotics - Caenorhabditis elegans [Pathway:R-GGA-211981] Xenobiotics - Gallus gallus [Pathway:R-XTR-211981] Xenobiotics - Xenopus tropicalis [Pathway:R-DRE-211981] Xenobiotics - Danio rerio [Pathway:R-SSC-211981] Xenobiotics - Sus scrofa [Pathway:R-BTA-211981] Xenobiotics - Bos taurus [Pathway:R-CFA-211981] Xenobiotics - Canis familiaris [Pathway:R-RNO-211981] Xenobiotics - Rattus norvegicus [Pathway:R-MMU-211981] Xenobiotics - Mus musculus
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-211981
summation	[Summation:266251] Of the 50 microsomal CYPs, 15 act on xenobiotics. They all p...
updateTrackers	[UpdateTracker:9778773] Update Tracker - [Pathway:211981] Xenobiotics - v67:[updateContainedRLE] [UpdateTracker:9791582] Update Tracker - [Pathway:211981] Xenobiotics - v28:[updateIndirectRLE] [UpdateTracker:9791713] Update Tracker - [Pathway:211981] Xenobiotics - v27:[updateContainedRLE] [UpdateTracker:9842261] Update Tracker - [Pathway:211981] Xenobiotics - v86:[updateContainedRLE] [UpdateTracker:9782448] Update Tracker - [Pathway:211981] Xenobiotics - v59:[updateContainedRLE] [UpdateTracker:9786561] Update Tracker - [Pathway:211981] Xenobiotics - v49:[updateContainedRLE] [UpdateTracker:9790555] Update Tracker - [Pathway:211981] Xenobiotics - v33:[addHasEvent, updateIndirectRLE]

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[Pathway:R-HSA-211897] Cytochrome P450 - arranged by substrate type

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