Coumarin is 7-hydroxylated by CYP2A6

Stable Identifier
R-HSA-76453
Type
Reaction
Species
Homo sapiens
Compartment
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The 7-hydroxylation of coumarin is used as an assay of P450 activity in animal and human liver microsomes. CYP2A6 is the major coumarin 7-hydroxylase in human liver.

Literature References
PubMed ID Title Journal Year
15665333 Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6

Kim, KH, Yun, CH, Calcutt, MW, Guengerich, FP

J Biol Chem 2005
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Event Information
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Catalyst Activity

coumarin 7-hydroxylase activity of Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane]

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