Reactome | Coumarin is 7-hydroxylated by CYP2A6

Schema > Reaction > Entries

Coumarin is 7-hydroxylated by CYP2A6 Show undefined attributes

catalystActivity	[CatalystActivity:11001674] coumarin 7-hydroxylase activity of Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen [Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11001676
displayName	Coumarin is 7-hydroxylated by CYP2A6
eventOf	[Pathway:R-DDI-211981] Xenobiotics - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5335] coumarin metabolic process
inferredFrom	[Reaction:R-HSA-76453] Coumarin is 7-hydroxylated by CYP2A6 - Homo sapiens
input	[SimpleEntity:R-ALL-76328] COUM [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Coumarin is 7-hydroxylated by CYP2A6
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-76452] HCOU [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-76453
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-211981] Xenobiotics
(inferredTo)	[Reaction:R-HSA-76453] Coumarin is 7-hydroxylated by CYP2A6