Reactome | Benzene is hydroxylated to phenol

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Benzene is hydroxylated to phenol Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:76353] monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
dbId	76416
displayName	Benzene is hydroxylated to phenol
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-211999] CYP2E1 reactions - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:11828] benzene metabolic process
input	[SimpleEntity:R-ALL-31711] C6H6 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:211822] Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Benzene is hydroxylated to phenol Benzene + O₂ + NADPH + H⁺ -> Phenol + H₂O + NADP⁺
orthologousEvent	[Reaction:R-DDI-76416] Benzene is hydroxylated to phenol - Dictyostelium discoideum [Reaction:R-CEL-76416] Benzene is hydroxylated to phenol - Caenorhabditis elegans [Reaction:R-GGA-76416] Benzene is hydroxylated to phenol - Gallus gallus [Reaction:R-XTR-76416] Benzene is hydroxylated to phenol - Xenopus tropicalis [Reaction:R-DRE-76416] Benzene is hydroxylated to phenol - Danio rerio [Reaction:R-SSC-76416] Benzene is hydroxylated to phenol - Sus scrofa [Reaction:R-BTA-76416] Benzene is hydroxylated to phenol - Bos taurus [Reaction:R-CFA-76416] Benzene is hydroxylated to phenol - Canis familiaris [Reaction:R-RNO-76416] Benzene is hydroxylated to phenol - Rattus norvegicus [Reaction:R-MMU-76416] Benzene is hydroxylated to phenol - Mus musculus
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-29630] PhOH [endoplasmic reticulum lumen]
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-76416
summation	[Summation:178502] Benzene is an occupational and environmental toxicant and is...
updateTrackers	[UpdateTracker:9792035] Update Tracker - [Reaction:76416] Benzene is hydroxylated to phenol - v24:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792035] Update Tracker - [Reaction:76416] Benzene is hydroxylated to phenol - v24:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-211999] CYP2E1 reactions