Benzene is hydroxylated to phenol

Stable Identifier
R-HSA-76416
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Benzene + O2 + NADPH + H+ -> Phenol + H2O + NADP+
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Benzene is an occupational and environmental toxicant and is implicated in myelogenous leukemia. For toxicity to occur, benzene is oxidised to phenol and subsequently to catechol and hydroquinone. CYP2E1 is the enzyme responsible for oxidation of benzene to phenol.

Literature References
PubMed ID Title Journal Year
11701230 Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite

Powley, MW, Carlson, GP

Toxicol Lett 2001
Participants
Participant Of
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Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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