Benzene is an occupational and environmental toxicant and is implicated in myelogenous leukemia. For toxicity to occur, benzene is oxidised to phenol and subsequently to catechol and hydroquinone. CYP2E1 is the enzyme responsible for oxidation of benzene to phenol.
Carlson, GP, Powley, MW
monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
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