Benzene is hydroxylated to phenol

Stable Identifier
R-HSA-76416
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
Synonyms
Benzene + O2 + NADPH + H+ -> Phenol + H2O + NADP+
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Benzene is hydroxylated to phenol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Benzene is an occupational and environmental toxicant and is implicated in myelogenous leukemia. For toxicity to occur, benzene is oxidised to phenol and subsequently to catechol and hydroquinone. CYP2E1 is the enzyme responsible for oxidation of benzene to phenol.
Literature References
PubMed ID Title Journal Year
11701230 Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite

Powley, MW, Carlson, GP

Toxicol Lett 2001
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
benzene metabolic process (0018910)
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
Benzene is hydroxylated to phenol (Bos taurus)
Benzene is hydroxylated to phenol (Caenorhabditis elegans)
Benzene is hydroxylated to phenol (Canis familiaris)
Benzene is hydroxylated to phenol (Danio rerio)
Benzene is hydroxylated to phenol (Dictyostelium discoideum)
Benzene is hydroxylated to phenol (Gallus gallus)
Benzene is hydroxylated to phenol (Mus musculus)
Benzene is hydroxylated to phenol (Rattus norvegicus)
Benzene is hydroxylated to phenol (Sus scrofa)
Benzene is hydroxylated to phenol (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2003-08-05)
Cite Us!