Reactome | Benzene is hydroxylated to phenol

Schema > Reaction > Entries

Benzene is hydroxylated to phenol Show undefined attributes

catalystActivity	[CatalystActivity:10452940] monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10452955
displayName	Benzene is hydroxylated to phenol
eventOf	[Pathway:R-SSC-211999] CYP2E1 reactions - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:11828] benzene metabolic process
inferredFrom	[Reaction:R-HSA-76416] Benzene is hydroxylated to phenol - Homo sapiens
input	[SimpleEntity:R-ALL-31711] C6H6 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Benzene is hydroxylated to phenol Benzene + O₂ + NADPH + H⁺ -> Phenol + H₂O + NADP⁺
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-29630] PhOH [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-76416
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-211999] CYP2E1 reactions
(inferredTo)	[Reaction:R-HSA-76416] Benzene is hydroxylated to phenol

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