Reactome | GP1b-IX-V activation signalling

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GP1b-IX-V activation signalling Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:430114] Jupe, S, 2009-07-30
crossReference	[DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940
dbId	430116
displayName	GP1b-IX-V activation signalling
edited	[InstanceEdit:870306] Jupe, S, 2010-06-07
eventOf	[Pathway:R-HSA-76002] Platelet activation, signaling and aggregation - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-114671] vWF binds to collagen - Homo sapiens [Reaction:R-HSA-114670] GPIb-IX-V binds to vWF:Collagen complex - Homo sapiens [Reaction:R-HSA-430076] GP1b-IX-V binds 14-3-3-zeta - Homo sapiens [Reaction:R-HSA-430073] GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress - Homo sapiens [Reaction:R-HSA-430096] GP1b-IX-V binds filamin - Homo sapiens [Reaction:R-HSA-443402] GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K - Homo sapiens [BlackBoxEvent:R-HSA-443418] GP1b signaling involves c-Src - Homo sapiens [Reaction:R-HSA-443439] c-Src binds Raf1 - Homo sapiens [Reaction:R-HSA-443831] 14-3-3-zeta binds Raf1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-10-05
literatureReference	[LiteratureReference:430081] Platelet physiology and thrombosis [LiteratureReference:870285] Adhesion mechanisms in platelet function
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	GP1b-IX-V activation signalling
orthologousEvent	[Pathway:R-PFA-430116] GP1b-IX-V activation signalling - Plasmodium falciparum [Pathway:R-CEL-430116] GP1b-IX-V activation signalling - Caenorhabditis elegans [Pathway:R-DME-430116] GP1b-IX-V activation signalling - Drosophila melanogaster [Pathway:R-GGA-430116] GP1b-IX-V activation signalling - Gallus gallus [Pathway:R-XTR-430116] GP1b-IX-V activation signalling - Xenopus tropicalis [Pathway:R-DRE-430116] GP1b-IX-V activation signalling - Danio rerio [Pathway:R-BTA-430116] GP1b-IX-V activation signalling - Bos taurus [Pathway:R-CFA-430116] GP1b-IX-V activation signalling - Canis familiaris [Pathway:R-RNO-430116] GP1b-IX-V activation signalling - Rattus norvegicus [Pathway:R-MMU-430116] GP1b-IX-V activation signalling - Mus musculus
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-430116
summation	[Summation:430115] The platelet GPIb complex (GP1b-IX-V) together with GPVI are...
updateTrackers	[UpdateTracker:9782812] Update Tracker - [Pathway:430116] GP1b-IX-V activation signalling - v58:[updateContainedRLE] [UpdateTracker:9853250] Update Tracker - [Pathway:430116] GP1b-IX-V activation signalling - v87:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9782812] Update Tracker - [Pathway:430116] GP1b-IX-V activation signalling - v58:[updateContainedRLE] [UpdateTracker:9853250] Update Tracker - [Pathway:430116] GP1b-IX-V activation signalling - v87:[addHasEvent, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-76002] Platelet activation, signaling and aggregation

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