Reactome | Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta

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Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta Show undefined attributes

catalystActivity	[CatalystActivity:2022841] protein serine/threonine kinase activity of GSK3B [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:75804] Matthews, L, 2003-09-01 04:23:00
dbId	75820
displayName	Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
eventOf	[Pathway:R-HSA-75815] Ubiquitin-dependent degradation of Cyclin D - Homo sapiens
followingEvent	[Reaction:R-HSA-75822] Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm - Homo sapiens
inferredFrom	[Reaction:R-MMU-182564] Phosphorylation of Cyclin D1 on Thr-286 by GSK-3 beta - Mus musculus
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-113844] CDK4:CCND1 [nucleoplasm]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:184187] Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-75812] phospho(T286)-Cyclin D1:Cdk4 [nucleoplasm]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-75820
summation	[Summation:179052] At the beginning of this reaction, 1 molecule of 'Cyclin D1:...
updateTrackers	[UpdateTracker:9779875] Update Tracker - [Reaction:75820] Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta - v64:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9779875] Update Tracker - [Reaction:75820] Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta - v64:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-75815] Ubiquitin-dependent degradation of Cyclin D
(precedingEvent)	[Reaction:R-HSA-75822] Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm
(inferredTo)	[Reaction:R-MMU-182564] Phosphorylation of Cyclin D1 on Thr-286 by GSK-3 beta

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