Reactome | Ubiquitin-dependent degradation of Cyclin D

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Ubiquitin-dependent degradation of Cyclin D Show undefined attributes

created	[InstanceEdit:68869] Walworth, N, O'Donnell, M, 2003-06-05
crossReference	[DatabaseIdentifier:12325574] BioModels Database:BIOMD0000000634
dbId	75815
displayName	Ubiquitin-dependent degradation of Cyclin D
eventOf	[Pathway:R-HSA-69242] S Phase - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160432] proteasome-mediated ubiquitin-dependent protein catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-75820] Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta - Homo sapiens [Reaction:R-HSA-75822] Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm - Homo sapiens [Reaction:R-HSA-75823] Relocalization of nuclearly localized Cyclin D1 to the cytoplasm - Homo sapiens [Reaction:R-HSA-75824] Ubiquitination of Cyclin D1 - Homo sapiens [BlackBoxEvent:R-HSA-75825] Proteasome mediated degradation of Cyclin D1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:212962] Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Ubiquitin-dependent degradation of Cyclin D
orthologousEvent	[Pathway:R-MMU-75815] Ubiquitin-dependent degradation of Cyclin D - Mus musculus [Pathway:R-SPO-75815] Ubiquitin-dependent degradation of Cyclin D - Schizosaccharomyces pombe [Pathway:R-CEL-75815] Ubiquitin-dependent degradation of Cyclin D - Caenorhabditis elegans [Pathway:R-DME-75815] Ubiquitin-dependent degradation of Cyclin D - Drosophila melanogaster [Pathway:R-GGA-75815] Ubiquitin-dependent degradation of Cyclin D - Gallus gallus [Pathway:R-XTR-75815] Ubiquitin-dependent degradation of Cyclin D - Xenopus tropicalis [Pathway:R-DRE-75815] Ubiquitin-dependent degradation of Cyclin D - Danio rerio [Pathway:R-SSC-75815] Ubiquitin-dependent degradation of Cyclin D - Sus scrofa [Pathway:R-BTA-75815] Ubiquitin-dependent degradation of Cyclin D - Bos taurus [Pathway:R-CFA-75815] Ubiquitin-dependent degradation of Cyclin D - Canis familiaris [Pathway:R-RNO-75815] Ubiquitin-dependent degradation of Cyclin D - Rattus norvegicus
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-75815
summation	[Summation:212979] Cyclin D turnover is regulated by ubiquitination and protea...

Referrals

(hasEvent)

[Pathway:R-HSA-69242] S Phase