Reactome | TRAIL signaling

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TRAIL signaling Show undefined attributes

authored	[InstanceEdit:141084] Gillespie, ME, 2004-08-31 03:31:31
created	[InstanceEdit:110071] Tschopp, J�rg, 2004-01-28
crossReference	[DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220
dbId	75158
displayName	TRAIL signaling
edited	[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-73887] Death Receptor Signaling - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-75238] TRAIL binds TRAIL receptors - Homo sapiens [Reaction:R-HSA-141139] Trimerization of TRAIL:TRAIL receptor complex - Homo sapiens [Reaction:R-HSA-75187] TRAIL:TRAIL receptor trimers bind FADD - Homo sapiens [Reaction:R-HSA-75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 - Homo sapiens [Reaction:R-HSA-141316] TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 - Homo sapiens [Reaction:R-HSA-5635741] TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-03-26
literatureReference	[LiteratureReference:140992] TRAIL and apoptosis induction by TNF-family death receptors
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	TRAIL signaling
orthologousEvent	[Pathway:R-MMU-75158] TRAIL signaling - Mus musculus [Pathway:R-RNO-75158] TRAIL signaling - Rattus norvegicus [Pathway:R-GGA-75158] TRAIL signaling - Gallus gallus [Pathway:R-DRE-75158] TRAIL signaling - Danio rerio [Pathway:R-SSC-75158] TRAIL signaling - Sus scrofa
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-75158
summation	[Summation:141083] Tumor necrosis factor-related apoptosis-inducing ligand or A...
updateTrackers	[UpdateTracker:9787422] Update Tracker - [Pathway:75158] TRAIL signaling - v45:[modifyText, updateContainedRLE] [UpdateTracker:9786383] Update Tracker - [Pathway:75158] TRAIL signaling - v49:[updateContainedRLE] [UpdateTracker:9787657] Update Tracker - [Pathway:75158] TRAIL signaling - v44:[updateContainedRLE] [UpdateTracker:9779896] Update Tracker - [Pathway:75158] TRAIL signaling - v64:[addHasEvent] [UpdateTracker:9788255] Update Tracker - [Pathway:75158] TRAIL signaling - v43:[updateContainedRLE] [UpdateTracker:9785723] Update Tracker - [Pathway:75158] TRAIL signaling - v51:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9787422] Update Tracker - [Pathway:75158] TRAIL signaling - v45:[modifyText, updateContainedRLE] [UpdateTracker:9786383] Update Tracker - [Pathway:75158] TRAIL signaling - v49:[updateContainedRLE] [UpdateTracker:9787657] Update Tracker - [Pathway:75158] TRAIL signaling - v44:[updateContainedRLE] [UpdateTracker:9779896] Update Tracker - [Pathway:75158] TRAIL signaling - v64:[addHasEvent] [UpdateTracker:9788255] Update Tracker - [Pathway:75158] TRAIL signaling - v43:[updateContainedRLE] [UpdateTracker:9785723] Update Tracker - [Pathway:75158] TRAIL signaling - v51:[updateContainedRLE]
(hasEncapsulatedEvent)	[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes [Pathway:R-HSA-5357769] Caspase activation via extrinsic apoptotic signalling pathway
(hasEvent)	[Pathway:R-HSA-73887] Death Receptor Signaling

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