Reactome | TRAIL signaling

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TRAIL signaling Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10647756
displayName	TRAIL signaling
eventOf	[Pathway:R-DRE-73887] Death Receptor Signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-75238] TRAIL binds TRAIL receptors - Danio rerio [Reaction:R-DRE-141139] Trimerization of TRAIL:TRAIL receptor complex - Danio rerio [Reaction:R-DRE-75187] TRAIL:TRAIL receptor trimers bind FADD - Danio rerio [Reaction:R-DRE-75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 - Danio rerio [Reaction:R-DRE-141316] TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 - Danio rerio [Reaction:R-DRE-5635741] TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 - Danio rerio
inferredFrom	[Pathway:R-HSA-75158] TRAIL signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TRAIL signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-75158
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-DRE-5633008] TP53 Regulates Transcription of Cell Death Genes [Pathway:R-DRE-5357769] Caspase activation via extrinsic apoptotic signalling pathway
(hasEvent)	[Pathway:R-DRE-73887] Death Receptor Signaling
(inferredTo)	[Pathway:R-HSA-75158] TRAIL signaling

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