Reactome | TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2

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TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 Show undefined attributes

authored	[InstanceEdit:5633001] Orlic-Milacic, Marija, 2014-10-29
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5635739] Orlic-Milacic, Marija, 2014-11-07
dbId	5635741
displayName	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2
edited	[InstanceEdit:8948870] Jupe, Steve, 2016-11-17
eventOf	[Pathway:R-HSA-75158] TRAIL signaling - Homo sapiens [Pathway:R-HSA-202733] Cell surface interactions at the vascular wall - Homo sapiens
input	[DefinedSet:R-HSA-5634815] TNFRSF10A,TNFRSF10B [plasma membrane] 2 × [EntityWithAccessionedSequence:R-HSA-5633374] TNFRSF10D [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5635736] Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexes [LiteratureReference:5635742] An antagonist decoy receptor and a death domain-containing receptor for TRAIL
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 TNFRSF10D binds TNFRSF10A or TNFRSF10B
orthologousEvent	[Reaction:R-MMU-5635741] TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 - Mus musculus [Reaction:R-GGA-5635741] TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 - Gallus gallus [Reaction:R-DRE-5635741] TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 - Danio rerio [Reaction:R-SSC-5635741] TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 - Sus scrofa [Reaction:R-RNO-5635741] TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 - Rattus norvegicus
output	[DefinedSet:R-HSA-5635735] TNFRSF10A,B:TNFRSF10D [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-5633441] TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes - Homo sapiens
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8878008] Ware, Carl F, Virgen-Slane, Richard, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5635741
summation	[Summation:5635737] TNFRSF10D (also known as DcR2 or TRAILR4) inhibits pro-apopt...

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