Reactome | NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)

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NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) Show undefined attributes

authored	[InstanceEdit:159103] Joshi-Tope, G, 2005-02-17 16:25:28
catalystActivity	[CatalystActivity:8849114] ATP hydrolysis activity of polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643605] ATPase activity of polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:159634] Zhang, Z, Krainer, AR, 2005-03-11 19:55:50
dbId	159101
displayName	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)
edited	[InstanceEdit:165073] Joshi-Tope, G, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-159236] Transport of Mature mRNA derived from an Intron-Containing Transcript - Homo sapiens
followingEvent	[Reaction:R-HSA-75096] Docking of the TAP:EJC Complex with the NPC - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1101] RNA export from nucleus
input	[Complex:R-HSA-8849118] NXF1,2:NXT1 [nucleoplasm] [Complex:R-HSA-156769] polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8850607] Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP [LiteratureReference:8850632] TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export [LiteratureReference:8850641] Mapping interactions between mRNA export factors in living cells [LiteratureReference:8850630] Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1 [LiteratureReference:8850666] The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA [LiteratureReference:8850614] Chtop is a component of the dynamic TREX mRNA export complex [LiteratureReference:8849125] Binding of ATP to UAP56 is necessary for mRNA export [LiteratureReference:8850715] TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus [LiteratureReference:8850681] The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences [LiteratureReference:8850709] The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human [LiteratureReference:8850704] Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor [LiteratureReference:8850694] Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes [LiteratureReference:8932923] TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) Recruitment of TAP to the EJC
orthologousEvent	[Reaction:R-CEL-159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - Caenorhabditis elegans [Reaction:R-DME-159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - Drosophila melanogaster [Reaction:R-DRE-159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - Danio rerio [Reaction:R-SSC-159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - Sus scrofa [Reaction:R-BTA-159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - Bos taurus [Reaction:R-RNO-159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - Rattus norvegicus [Reaction:R-MMU-159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - Mus musculus
output	[Complex:R-HSA-8849115] DDX39B:ADP [nucleoplasm] [Complex:R-HSA-159100] NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8849157] TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8852183] Wilson, Stuart A, 2016-01-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-159101
summation	[Summation:159102] The mRNA is transferred from ALYREF of the TREX complex to N...
updateTrackers	[UpdateTracker:9783502] Update Tracker - [Reaction:159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - v56:[addCatalystActivity, addLiteratureReference, addOutput, add_removeInput, modifyText] [UpdateTracker:9782742] Update Tracker - [Reaction:159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - v58:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9783502] Update Tracker - [Reaction:159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - v56:[addCatalystActivity, addLiteratureReference, addOutput, add_removeInput, modifyText] [UpdateTracker:9782742] Update Tracker - [Reaction:159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - v58:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-159236] Transport of Mature mRNA derived from an Intron-Containing Transcript
(precedingEvent)	[Reaction:R-HSA-75096] Docking of the TAP:EJC Complex with the NPC

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