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Schema
>
Reaction
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Entries
ADA catalyzes the deamination of (deoxy)adenosine
Show undefined attributes
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catalystActivity
[CatalystActivity:74234] deaminase activity of ADA [cytosol]
catalystActivityReference
[CatalystActivityReference:9643062] deaminase activity of ADA [cytosol] Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference
[DatabaseIdentifier:12667760] RHEA:24409
[DatabaseIdentifier:12667761] RHEA:28191
[DatabaseIdentifier:9976251] RHEA:24409
[DatabaseIdentifier:9976254] RHEA:28191
dbId
74241
deleted
[Deleted:500176] Deletion of instance: 74235
diseaseReaction
[FailedReaction:R-HSA-9734745] Defective ADA does not deaminate (deoxy)adenosine - Homo sapiens
displayName
ADA catalyzes the deamination of (deoxy)adenosine
eventOf
[Pathway:R-HSA-74217] Purine salvage - Homo sapiens
followingEvent
[Reaction:R-HSA-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Homo sapiens
input
[DefinedSet:R-ALL-500173] Ade-Rib, dA [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:200141] Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
ADA catalyzes the deamination of (deoxy)adenosine
adenosine + H2O + H(+) => inosine + NH4(+)
2'-deoxyadenosine + H2O + H(+) => 2'-deoxyinosine + NH4(+)
(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)
orthologousEvent
[Reaction:R-PFA-74241] ADA catalyzes the deamination of (deoxy)adenosine - Plasmodium falciparum
[Reaction:R-DDI-74241] ADA catalyzes the deamination of (deoxy)adenosine - Dictyostelium discoideum
[Reaction:R-CEL-74241] ADA catalyzes the deamination of (deoxy)adenosine - Caenorhabditis elegans
[Reaction:R-GGA-74241] ADA catalyzes the deamination of (deoxy)adenosine - Gallus gallus
[Reaction:R-XTR-74241] ADA catalyzes the deamination of (deoxy)adenosine - Xenopus tropicalis
[Reaction:R-DRE-74241] ADA catalyzes the deamination of (deoxy)adenosine - Danio rerio
[Reaction:R-SSC-74241] ADA catalyzes the deamination of (deoxy)adenosine - Sus scrofa
[Reaction:R-BTA-74241] ADA catalyzes the deamination of (deoxy)adenosine - Bos taurus
[Reaction:R-CFA-74241] ADA catalyzes the deamination of (deoxy)adenosine - Canis familiaris
[Reaction:R-RNO-74241] ADA catalyzes the deamination of (deoxy)adenosine - Rattus norvegicus
[Reaction:R-MMU-74241] ADA catalyzes the deamination of (deoxy)adenosine - Mus musculus
output
[DefinedSet:R-ALL-500172] Ino, dI [cytosol]
[SimpleEntity:R-ALL-31633] NH4+ [cytosol]
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2004-07-06
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
revised
[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-74241
summation
[Summation:178260] Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis...
updateTrackers
[UpdateTracker:9791080] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v32:[add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9781584] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v60:[add_removeOutput]
[UpdateTracker:9984672] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v96:[removeInput]
[UpdateTracker:9792396] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v22:[addLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9791080] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v32:[add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9781584] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v60:[add_removeOutput]
[UpdateTracker:9984672] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v96:[removeInput]
[UpdateTracker:9792396] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v22:[addLiteratureReference]
(replacementInstances)
[Deleted:500176] Deletion of instance: 74235
(normalReaction)
[FailedReaction:R-HSA-9734745] Defective ADA does not deaminate (deoxy)adenosine
(hasEvent)
[Pathway:R-HSA-74217] Purine salvage
(precedingEvent)
[Reaction:R-HSA-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose
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