ADA catalyzes the deamination of (deoxy)adenosine

Stable Identifier
R-HSA-74241
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)
ReviewStatus
5/5
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ADA catalyzes the deamination of (deoxy)adenosine
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Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis of 2'deoxyadenosine and adenosine to yield deoxyinosine and inosine, respectively, plus ammonia (Akeson et al. 1988). Unpublished crystallographic data (PDB 3IAR) indicate that the human enzyme is a monomer.
Literature References
PubMed ID Title Journal Year
3182793 Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts

Hutton, JJ, States, JC, Wiginton, DA, Akeson, AL, Dusing, MR

J Biol Chem 1988
Participants
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Output
Participates
as an event of
Catalyst Activity

deaminase activity of ADA [cytosol]

Physical Entity
ADA [cytosol] (Homo sapiens)
Activity
deaminase activity (GO:0019239)
Orthologous Events
ADA catalyzes the deamination of (deoxy)adenosine (Bos taurus)
ADA catalyzes the deamination of (deoxy)adenosine (Caenorhabditis elegans)
ADA catalyzes the deamination of (deoxy)adenosine (Canis familiaris)
ADA catalyzes the deamination of (deoxy)adenosine (Danio rerio)
ADA catalyzes the deamination of (deoxy)adenosine (Dictyostelium discoideum)
ADA catalyzes the deamination of (deoxy)adenosine (Gallus gallus)
ADA catalyzes the deamination of (deoxy)adenosine (Mus musculus)
ADA catalyzes the deamination of (deoxy)adenosine (Plasmodium falciparum)
ADA catalyzes the deamination of (deoxy)adenosine (Rattus norvegicus)
ADA catalyzes the deamination of (deoxy)adenosine (Sus scrofa)
ADA catalyzes the deamination of (deoxy)adenosine (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2003-07-17)
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