ADA catalyzes the deamination of (deoxy)adenosine

Stable Identifier
R-HSA-74241
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)
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Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis of 2'deoxyadenosine and adenosine to yield deoxyinosine and inosine, respectively, plus ammonia (Akeson et al. 1988). Unpublished crystallographic data (PDB 3IAR) indicate that the human enzyme is a monomer.

Literature References
PubMed ID Title Journal Year
3182793 Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts

Hutton, JJ, States, JC, Wiginton, DA, Akeson, AL, Dusing, MR

J Biol Chem 1988
Participants
Participates
Catalyst Activity

deaminase activity of ADA [cytosol]

Orthologous Events
Cross References
Rhea
Created
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