Reactome | ADA catalyzes the deamination of (deoxy)adenosine

ADA catalyzes the deamination of (deoxy)adenosine

Stable Identifier

R-HSA-74241

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)

ReviewStatus

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ADA catalyzes the deamination of (deoxy)adenosine

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Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis of 2'deoxyadenosine and adenosine to yield deoxyinosine and inosine, respectively, plus ammonia (Akeson et al. 1988). Unpublished crystallographic data (PDB 3IAR) indicate that the human enzyme is a monomer.

Literature References

PubMed ID	Title	Journal	Year
3182793	Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts Hutton, JJ, States, JC, Wiginton, DA, Akeson, AL, Dusing, MR	J Biol Chem	1988