Reactome | acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH

Schema > Reaction > Entries

acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH Show undefined attributes

catalystActivity	[CatalystActivity:10918253] hydroxymethylglutaryl-CoA synthase activity of HMGCS2 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10918255
displayName	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
eventOf	[Pathway:R-CEL-77111] Synthesis of Ketone Bodies - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-74180] HMG CoA => acetoacetic acid + acetyl CoA - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Homo sapiens
input	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-73871] ACA-CoA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
output	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-73917] HMG CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-CEL-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-73918
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-77111] Synthesis of Ketone Bodies
(precedingEvent)	[Reaction:R-CEL-74180] HMG CoA => acetoacetic acid + acetyl CoA
(inferredTo)	[Reaction:R-HSA-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH

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