acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH

Stable Identifier
R-HSA-73918
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Hydroxymethylglutaryl-CoA synthase tetramer (HMGCS2) in the mitochondrial matrix catalyzes the reaction of acetoacetyl-CoA and acetyl-CoA to form beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) and CoA (Aledo et al. 2001).

Literature References
PubMed ID Title Journal Year
11479731 Genetic basis of mitochondrial HMG-CoA synthase deficiency

Aledo, R, Zschocke, J, Pie, J, Mir, C, Fiesel, S, Mayatepek, E, Hoffmann, GF, Casals, N, Hegardt, FG

Hum Genet 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
hydroxymethylglutaryl-CoA synthase activity of HMGCS2 [mitochondrial matrix]
Physical Entity
HMGCS2 [mitochondrial matrix]
Activity
hydroxymethylglutaryl-CoA synthase activity (0004421)
Orthologous Events
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Bos taurus)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Caenorhabditis elegans)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Canis familiaris)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Danio rerio)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Dictyostelium discoideum)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Drosophila melanogaster)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Gallus gallus)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Mus musculus)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Rattus norvegicus)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Saccharomyces cerevisiae)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Schizosaccharomyces pombe)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Sus scrofa)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Xenopus tropicalis)
Created
Gopinathrao, G  (2003-07-16)