acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH

Stable Identifier
R-HSA-73918
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
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Hydroxymethylglutaryl-CoA synthase tetramer (HMGCS2) in the mitochondrial matrix catalyzes the reaction of acetoacetyl-CoA and acetyl-CoA to form beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) and CoA (Aledo et al. 2001).
Literature References
PubMed ID Title Journal Year
11479731 Genetic basis of mitochondrial HMG-CoA synthase deficiency

Aledo, R, Zschocke, J, Pie, J, Mir, C, Fiesel, S, Mayatepek, E, Hoffmann, GF, Casals, N, Hegardt, FG

Hum Genet 2001
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Catalyst Activity

hydroxymethylglutaryl-CoA synthase activity of HMGCS2 [mitochondrial matrix]

Physical Entity
HMGCS2 [mitochondrial matrix] (Homo sapiens)
Activity
hydroxymethylglutaryl-CoA synthase activity (GO:0004421)
Orthologous Events
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Bos taurus)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Caenorhabditis elegans)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Canis familiaris)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Dictyostelium discoideum)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Drosophila melanogaster)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Gallus gallus)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Mus musculus)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Rattus norvegicus)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Saccharomyces cerevisiae)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Schizosaccharomyces pombe)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Sus scrofa)
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Xenopus tropicalis)
Cross References
RHEA
Created
Gopinathrao, G  (2003-07-16)
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