Hydroxymethylglutaryl-CoA synthase tetramer (HMGCS2) in the mitochondrial matrix catalyzes the reaction of acetoacetyl-CoA and acetyl-CoA to form beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) and CoA (Aledo et al. 2001).
Hoffmann, GF, Casals, N, Pie, J, Aledo, R, Hegardt, FG, Zschocke, J, Mayatepek, E, Fiesel, S, Mir, C
hydroxymethylglutaryl-CoA synthase activity of HMGCS2 [mitochondrial matrix]
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