AICAR + 10-Formyl-THF => FAICAR + THF

Stable Identifier
R-HSA-73798
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
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The irreversible transfer of a formyl group to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR), to yield 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR), is catalyzed by the phosphoribosylaminoimidazolecarboxamide formyltransferase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoribosylaminoimidazolecarboxamide formyltransferase activity of ATIC dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created