Reactome | AICAR + 10-Formyl-THF => FAICAR + THF

Schema > Reaction > Entries

AICAR + 10-Formyl-THF => FAICAR + THF Show undefined attributes

catalystActivity	[CatalystActivity:10107778] phosphoribosylaminoimidazolecarboxamide formyltransferase activity of ATIC dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10107780
displayName	AICAR + 10-Formyl-THF => FAICAR + THF
eventOf	[Pathway:R-RNO-73817] Purine ribonucleoside monophosphate biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-73797] FAICAR => IMP + H2O - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Homo sapiens
input	[SimpleEntity:R-ALL-419151] 10-formyl-THF [cytosol] [SimpleEntity:R-ALL-111409] AICAR [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AICAR + 10-Formyl-THF => FAICAR + THF (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
output	[SimpleEntity:R-ALL-111427] FAICAR [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
precedingEvent	[Reaction:R-RNO-73800] SAICAR => AICAR + Fumarate - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-73798
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-73817] Purine ribonucleoside monophosphate biosynthesis
(precedingEvent)	[Reaction:R-RNO-73797] FAICAR => IMP + H2O
(inferredTo)	[Reaction:R-HSA-73798] AICAR + 10-Formyl-THF => FAICAR + THF

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