Reactome | (d)GMP + ATP <=> (d)GDP + ADP (GUK1)

Schema > Reaction > Entries

(d)GMP + ATP <=> (d)GDP + ADP (GUK1) Show undefined attributes

catalystActivity	[CatalystActivity:74189] GMP kinase activity of GUK1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643996] guanylate kinase activity of GUK1 [cytosol] Cloning, characterization, and modeling of mouse and human guanylate kinases
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference	[DatabaseIdentifier:12668068] RHEA:12698 [DatabaseIdentifier:12668067] RHEA:20781 [DatabaseIdentifier:9975902] RHEA:20781 [DatabaseIdentifier:9975909] RHEA:12698
dbId	73788
deleted	[Deleted:500082] Deletion of instance: 74204 [Deleted:500081] Deletion of instance: 110116
displayName	(d)GMP + ATP <=> (d)GDP + ADP (GUK1)
eventOf	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
followingEvent	[Reaction:R-HSA-482619] (d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) - Homo sapiens
input	[DefinedSet:R-ALL-500071] (d)GMP [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:110117] Guanylate kinases from human erythrocytes, hog brain, and rat liver [LiteratureReference:500070] Cloning, characterization, and modeling of mouse and human guanylate kinases [LiteratureReference:110100] Studies on the properties and tissue distribution of the isozymes of guanylate kinase in man [LiteratureReference:110121] Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) GMP + ATP => GDP + ADP dGMP + ATP => dGDP + ADP
orthologousEvent	[Reaction:R-PFA-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Plasmodium falciparum [Reaction:R-SCE-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Saccharomyces cerevisiae [Reaction:R-SPO-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Schizosaccharomyces pombe [Reaction:R-DDI-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Dictyostelium discoideum [Reaction:R-CEL-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Caenorhabditis elegans [Reaction:R-DME-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Drosophila melanogaster [Reaction:R-GGA-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Gallus gallus [Reaction:R-XTR-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Xenopus tropicalis [Reaction:R-DRE-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Danio rerio [Reaction:R-SSC-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Sus scrofa [Reaction:R-BTA-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Bos taurus [Reaction:R-CFA-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Canis familiaris [Reaction:R-RNO-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Rattus norvegicus [Reaction:R-MMU-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Mus musculus
output	[DefinedSet:R-ALL-500077] (d)GDP [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-74207] dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) - Homo sapiens
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-110133] (d)GDP + ADP <=> (d)GMP + ATP (GUK1)
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73788
summation	[Summation:499941] Cytosolic guanylate kinase 1 (GUK1) catalyzes the reversible...
updateTrackers	[UpdateTracker:9790992] Update Tracker - [Reaction:73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9790992] Update Tracker - [Reaction:73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]
(replacementInstances)	[Deleted:500082] Deletion of instance: 74204 [Deleted:500081] Deletion of instance: 110116
(hasEvent)	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates
(precedingEvent)	[Reaction:R-HSA-482619] (d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)

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