Reactome | (d)GMP + ATP <=> (d)GDP + ADP (GUK1)

(d)GMP + ATP <=> (d)GDP + ADP (GUK1)

Stable Identifier

R-HSA-73788

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic guanylate kinase 1 (GUK1) catalyzes the reversible reactions of GMP and dGMP with ATP to form GDP and dGDP respectively and ADP. While native gel electrophoretic studies of whole cell extracts suggested the existence of multiple human enzymes with guanylate kinase activity (Jamil et al. 1975), only one has been purified and biochemically characterized (Agarwal et al. 1978; Brady et al. 1996). The enzyme is of clinical importance as it is a target of antitumor drugs and antiviral drugs such as acyclovir (Miller and Miller 1980).

Literature References

PubMed ID	Title	Journal	Year
6248551	Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase Miller, WH, Miller, RL	J Biol Chem	1980
177353	Studies on the properties and tissue distribution of the isozymes of guanylate kinase in man Jamil, T, Fisher, RA, Harris, H	Human Hered	1975
211390	Guanylate kinases from human erythrocytes, hog brain, and rat liver Agarwal, KC, Miech, RP, Parks, Jr, RE	Methods Enzymol	1978
8663313	Cloning, characterization, and modeling of mouse and human guanylate kinases Brady, WA, Kokoris, MS, Fitzgibbon, M, Black, ME	J Biol Chem	1996