Reactome | Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)

Schema > Reaction > Entries

Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) Show undefined attributes

catalystActivity	[CatalystActivity:73537] CTP synthase activity of CTPS tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643175] CTP synthase activity of CTPS tetramer [cytosol] Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:12668056] RHEA:26427 [DatabaseIdentifier:9975911] RHEA:26427
dbId	73647
displayName	Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)
eventOf	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
followingEvent	[Reaction:R-HSA-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol] [SimpleEntity:R-ALL-29494] UTP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200249] Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A [LiteratureReference:504059] Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) UTP + L-glutamine + ATP + H2O => CTP + L-glutamate + ADP + phosphate + 2 H(+)
orthologousEvent	[Reaction:R-MMU-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Mus musculus [Reaction:R-PFA-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Plasmodium falciparum [Reaction:R-SCE-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Saccharomyces cerevisiae [Reaction:R-SPO-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Schizosaccharomyces pombe [Reaction:R-DDI-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Dictyostelium discoideum [Reaction:R-DME-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Drosophila melanogaster [Reaction:R-GGA-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Gallus gallus [Reaction:R-XTR-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Xenopus tropicalis [Reaction:R-DRE-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Danio rerio [Reaction:R-SSC-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Sus scrofa [Reaction:R-BTA-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Bos taurus [Reaction:R-CFA-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Canis familiaris [Reaction:R-RNO-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Rattus norvegicus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-110614] CTP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73647
summation	[Summation:179322] Cytosolic CTP synthase 1 (CTPS) catalyzes the reaction of UT...
updateTrackers	[UpdateTracker:9790858] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792378] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v22:[addLiteratureReference] [UpdateTracker:9775860] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v78:[addOutput] [UpdateTracker:9791879] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v25:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9790858] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792378] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v22:[addLiteratureReference] [UpdateTracker:9775860] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v78:[addOutput] [UpdateTracker:9791879] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v25:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates
(precedingEvent)	[Reaction:R-HSA-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)

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