Reactome | Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)

Schema > Reaction > Entries

Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) Show undefined attributes

catalystActivity	[CatalystActivity:10336644] CTP synthase activity of CTPS tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10336646
displayName	Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)
eventOf	[Pathway:R-BTA-499943] Interconversion of nucleotide di- and triphosphates - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Bos taurus
inferredFrom	[Reaction:R-HSA-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol] [SimpleEntity:R-ALL-29494] UTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) UTP + L-glutamine + ATP + H2O => CTP + L-glutamate + ADP + phosphate + 2 H(+)
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-110614] CTP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-73647
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-499943] Interconversion of nucleotide di- and triphosphates
(precedingEvent)	[Reaction:R-BTA-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)
(inferredTo)	[Reaction:R-HSA-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)

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