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Schema
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Reaction
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Entries
(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)
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authored
[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
catalystActivity
[CatalystActivity:482613] nucleoside diphosphate kinase activity of NME1,2 hexamers [cytosol]
catalystActivityReference
[CatalystActivityReference:9643341] nucleoside diphosphate kinase activity of NME1,2 hexamers [cytosol] Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:482616] D'Eustachio, P, 2010-01-28
crossReference
[DatabaseIdentifier:12668070] RHEA:27688
[DatabaseIdentifier:9976234] RHEA:27688
[DatabaseIdentifier:12668069] RHEA:28584
[DatabaseIdentifier:9976223] RHEA:25239
[DatabaseIdentifier:9976219] RHEA:25100
[DatabaseIdentifier:9976232] RHEA:27676
[DatabaseIdentifier:9976233] RHEA:27692
[DatabaseIdentifier:9976220] RHEA:27680
[DatabaseIdentifier:9976229] RHEA:27684
[DatabaseIdentifier:9976217] RHEA:28584
dbId
482621
deleted
[Deleted:482615] Deletion of instances: 110729, 110727, 110725, 110717, 110715, 110713, 110705, 110703, 110701, 110698, 110692, 110690, 110688, 110684, 110679, 110677, 110675, 110667, 110665, 110663, 110659, 110651, 110649, 110647, 110635, 110620, 110616, 75129, 75127, 75124, 75122, 75121
[Deleted:482622] Deletion of instances: 110658, 110624, 110619, 110579
[Deleted:482815] Deletion of instance: 110580
displayName
(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)
edited
[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
eventOf
[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
input
[DefinedSet:R-ALL-482625] (d)NTP [cytosol]
[SimpleEntity:R-ALL-29370] ADP [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:110581] Enzymatic phosphorylation of nucleoside diphosphates
[LiteratureReference:482617] Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases
[LiteratureReference:110625] Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene
[LiteratureReference:110596] Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme
[Book:110590] The Enzymes, 3rd ed Boyer, PD Nucleoside diphosphokinases 0121227022
[LiteratureReference:110592] Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)
GTP + ADP => GDP + ATP
CTP + ADP => CDP + ATP
UTP + ADP => UDP + ATP
dATP + ADP => dADP + ATP
dGTP + ADP => dGDP + ATP
dCTP + ADP => dCDP + ATP
dTTP + ADP => dTDP + ATP
dUTP + ADP => dUDP + ATP
orthologousEvent
[Reaction:R-RNO-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Rattus norvegicus
[Reaction:R-CFA-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Canis familiaris
[Reaction:R-BTA-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Bos taurus
[Reaction:R-SSC-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Sus scrofa
[Reaction:R-DRE-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Danio rerio
[Reaction:R-XTR-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Xenopus tropicalis
[Reaction:R-GGA-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Gallus gallus
[Reaction:R-DME-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Drosophila melanogaster
[Reaction:R-CEL-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Caenorhabditis elegans
[Reaction:R-DDI-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Dictyostelium discoideum
[Reaction:R-SPO-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Schizosaccharomyces pombe
[Reaction:R-SCE-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Saccharomyces cerevisiae
[Reaction:R-PFA-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Plasmodium falciparum
[Reaction:R-MMU-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Mus musculus
output
[DefinedSet:R-ALL-482627] (d)NDP [cytosol]
[SimpleEntity:R-ALL-113592] ATP [cytosol]
precedingEvent
[Reaction:R-HSA-73647] Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS) - Homo sapiens
releaseDate
2010-03-16
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:165071] Graves, L, Rush, MG, 0000-00-00 00:00:00
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-482621
summation
[Summation:482624] Cytosolic nucleoside diphosphate kinases catalyze the revers...
Referrals
(hasEvent)
[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates
(reverseReaction)
[Reaction:R-HSA-482619] (d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)
(replacementInstances)
[Deleted:482815] Deletion of instance: 110580
[Deleted:482622] Deletion of instances: 110658, 110624, 110619, 110579
[Deleted:482615] Deletion of instances: 110729, 110727, 110725, 110717, 110715, 110713, 110705, 110703, 110701, 110698, 110692, 110690, 110688, 110684, 110679, 110677, 110675, 110667, 110665, 110663, 110659, 110651, 110649, 110647, 110635, 110620, 110616, 75129, 75127, 75124, 75122, 75121
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