cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]

Stable Identifier
R-HSA-73599
Type
Reaction
Species
Homo sapiens
Compartment
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Cytosolic uridine-cytidine kinase 1 (UCK1) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Unpublished crystallographic data show the enzyme to be a tetramer (PDB - 2JEO).

Literature References
PubMed ID Title Journal Year
195585 Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma

Webb, TE, Greenberg, N, Schumm, DE

Biochem J 1977
11306702 Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases

Linden, K, Van Rompay, AR, Norda, A, Karlsson, A, Johansson, M

Mol Pharmacol 2001
Participants
Participates
Catalyst Activity

nucleoside kinase activity of UCK1 tetramer [cytosol]

Orthologous Events
Cross References
Rhea
Created
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