Reactome | cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]

cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]

Stable Identifier

R-HSA-73599

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic uridine-cytidine kinase 1 (UCK1) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Unpublished crystallographic data show the enzyme to be a tetramer (PDB - 2JEO).

Literature References

PubMed ID	Title	Journal	Year
195585	Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma Webb, TE, Greenberg, N, Schumm, DE	Biochem J	1977
11306702	Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases Linden, K, Van Rompay, AR, Norda, A, Karlsson, A, Johansson, M	Mol Pharmacol	2001