Reactome | dCMP + H2O => dUMP + NH4+

Schema > Reaction > Entries

dCMP + H2O => dUMP + NH4+ Show undefined attributes

catalystActivity	[CatalystActivity:73593] dCMP deaminase activity of DCTD hexamer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643880] dCMP deaminase activity of DCTD hexamer [cytosol] Properties of an affinity-column-purified human deoxycytidylate deaminase
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:12668063] RHEA:22925 [DatabaseIdentifier:9976227] RHEA:22925
dbId	73596
displayName	dCMP + H2O => dUMP + NH4+
eventOf	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
followingEvent	[Reaction:R-HSA-73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] - Homo sapiens [Reaction:R-HSA-73605] conversion of dUMP to dTMP - Homo sapiens
input	[SimpleEntity:R-ALL-109378] dCMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200103] Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli [LiteratureReference:500734] Properties of an affinity-column-purified human deoxycytidylate deaminase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	dCMP + H2O => dUMP + NH4+ dCMP + H2O + H(+) => dUMP + NH4(+) deamination of dCMP to form dUMP
orthologousEvent	[Reaction:R-MMU-73596] dCMP + H2O => dUMP + NH4+ - Mus musculus [Reaction:R-SCE-73596] dCMP + H2O => dUMP + NH4+ - Saccharomyces cerevisiae [Reaction:R-SPO-73596] dCMP + H2O => dUMP + NH4+ - Schizosaccharomyces pombe [Reaction:R-CEL-73596] dCMP + H2O => dUMP + NH4+ - Caenorhabditis elegans [Reaction:R-DME-73596] dCMP + H2O => dUMP + NH4+ - Drosophila melanogaster [Reaction:R-GGA-73596] dCMP + H2O => dUMP + NH4+ - Gallus gallus [Reaction:R-XTR-73596] dCMP + H2O => dUMP + NH4+ - Xenopus tropicalis [Reaction:R-DRE-73596] dCMP + H2O => dUMP + NH4+ - Danio rerio [Reaction:R-SSC-73596] dCMP + H2O => dUMP + NH4+ - Sus scrofa [Reaction:R-BTA-73596] dCMP + H2O => dUMP + NH4+ - Bos taurus [Reaction:R-CFA-73596] dCMP + H2O => dUMP + NH4+ - Canis familiaris [Reaction:R-RNO-73596] dCMP + H2O => dUMP + NH4+ - Rattus norvegicus
output	[SimpleEntity:R-ALL-109382] dUMP [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
precedingEvent	[Reaction:R-HSA-73598] (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) - Homo sapiens [Reaction:R-HSA-75125] (d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73596
summation	[Summation:178288] Cytosolic deoxycytidylate deaminase (DCTD) catalyzes the hyd...
updateTrackers	[UpdateTracker:9790850] Update Tracker - [Reaction:73596] dCMP + H2O => dUMP + NH4+ - v32:[addLiteratureReference, modifyText] [UpdateTracker:9775602] Update Tracker - [Reaction:73596] dCMP + H2O => dUMP + NH4+ - v78:[addInput] [UpdateTracker:9781683] Update Tracker - [Reaction:73596] dCMP + H2O => dUMP + NH4+ - v60:[add_removeOutput] [UpdateTracker:9792349] Update Tracker - [Reaction:73596] dCMP + H2O => dUMP + NH4+ - v22:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9790850] Update Tracker - [Reaction:73596] dCMP + H2O => dUMP + NH4+ - v32:[addLiteratureReference, modifyText] [UpdateTracker:9775602] Update Tracker - [Reaction:73596] dCMP + H2O => dUMP + NH4+ - v78:[addInput] [UpdateTracker:9781683] Update Tracker - [Reaction:73596] dCMP + H2O => dUMP + NH4+ - v60:[add_removeOutput] [UpdateTracker:9792349] Update Tracker - [Reaction:73596] dCMP + H2O => dUMP + NH4+ - v22:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates
(precedingEvent)	[Reaction:R-HSA-73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] [Reaction:R-HSA-73605] conversion of dUMP to dTMP

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