Reactome | dCMP + H2O => dUMP + NH4+

dCMP + H2O => dUMP + NH4+

Stable Identifier

R-HSA-73596

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

dCMP + H2O + H(+) => dUMP + NH4(+), deamination of dCMP to form dUMP

ReviewStatus

5/5

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Cytosolic deoxycytidylate deaminase (DCTD) catalyzes the hydrolysis of dCMP (2'-deoxyuridine 5'-monophosphate) to yield dUMP (2'-deoxyuridine 5'-monophosphate) and ammonia. The active enzyme is a homohexamer (Maley et al. 1993; Weiner et al. 1993; unpublished crystallography data - PDB 2W4L).

Literature References

PubMed ID	Title	Journal	Year
8448179	Properties of an affinity-column-purified human deoxycytidylate deaminase Maley, GF, Lobo, AP, Maley, F	Biochim Biophys Acta	1993
7685356	Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli Weiner, KX, Weiner, RS, Maley, F, Maley, GF	J Biol Chem	1993