Reactome | Formation of translation initiation complexes containing mRNA that does not circularize

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Formation of translation initiation complexes containing mRNA that does not circularize Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:72607] Merrick, WC, 2002-12-16 00:00:00
dbId	157849
displayName	Formation of translation initiation complexes containing mRNA that does not circularize
eventOf	[Pathway:R-HSA-72649] Translation initiation complex formation - Homo sapiens
followingEvent	[Reaction:R-HSA-72621] Ribosomal scanning - Homo sapiens
input	[Complex:R-HSA-72571] 43S complex [cytosol] [EntityWithAccessionedSequence:R-HSA-72557] EIF1AX [cytosol] [Complex:R-HSA-72593] mRNA:eIF4F:eIF4B:eIF4H [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72650] The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes [LiteratureReference:72652] Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors [LiteratureReference:72636] New initiation factor activity required for globin mRNA translation [LiteratureReference:72657] Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Formation of translation initiation complexes containing mRNA that does not circularize
orthologousEvent	[Reaction:R-MMU-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Mus musculus [Reaction:R-PFA-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Plasmodium falciparum [Reaction:R-SCE-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Saccharomyces cerevisiae [Reaction:R-SPO-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Schizosaccharomyces pombe [Reaction:R-CEL-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Caenorhabditis elegans [Reaction:R-DME-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Drosophila melanogaster [Reaction:R-GGA-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Gallus gallus [Reaction:R-SSC-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Sus scrofa [Reaction:R-BTA-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Bos taurus [Reaction:R-CFA-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Canis familiaris [Reaction:R-RNO-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Rattus norvegicus
output	[Complex:R-HSA-72592] 43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] [EntityWithAccessionedSequence:R-HSA-72557] EIF1AX [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-72647] Cap-bound mRNA is activated by helicases - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-157849
summation	[Summation:72661] The translation initiation complex forms when the 43S comple...

Referrals

(hasEvent)	[Pathway:R-HSA-72649] Translation initiation complex formation
(precedingEvent)	[Reaction:R-HSA-72621] Ribosomal scanning