Reactome | PGK complexes dephosphorylate 1,3BPG

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PGK complexes dephosphorylate 1,3BPG Show undefined attributes

catalystActivity	[CatalystActivity:70485] phosphoglycerate kinase activity of PGK complexes [cytosol]
catalystActivityReference	[CatalystActivityReference:9643186] phosphoglycerate kinase activity of PGK complexes [cytosol] Human phosphoglycerate kinase. I. Crystallization and characterization of normal enzyme
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667607] RHEA:14803 [DatabaseIdentifier:9933516] RHEA:14803
dbId	71850
deleted	[Deleted:450680] Deletion of instance: 70105
displayName	PGK complexes dephosphorylate 1,3BPG
eventOf	[Pathway:R-HSA-70171] Glycolysis - Homo sapiens
followingEvent	[Reaction:R-HSA-71654] PGAM dimers isomerise 3PG to 2PG - Homo sapiens
input	[SimpleEntity:R-ALL-29800] 1,3BPG [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6808365] Characterization of phosphoglycerate kinase from human spermatozoa [LiteratureReference:141559] Complete amino acid sequence of human phosphoglycerate kinase. Isolation and amino acid sequence of tryptic peptides. [LiteratureReference:141486] Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence. [LiteratureReference:6807621] Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene [LiteratureReference:450670] Human phosphoglycerate kinase. I. Crystallization and characterization of normal enzyme
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PGK complexes dephosphorylate 1,3BPG 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP 1,3-Bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP
orthologousEvent	[Reaction:R-PFA-71850] PGK complexes dephosphorylate 1,3BPG - Plasmodium falciparum [Reaction:R-SCE-71850] PGK complexes dephosphorylate 1,3BPG - Saccharomyces cerevisiae [Reaction:R-SPO-71850] PGK complexes dephosphorylate 1,3BPG - Schizosaccharomyces pombe [Reaction:R-DDI-71850] PGK complexes dephosphorylate 1,3BPG - Dictyostelium discoideum [Reaction:R-CEL-71850] PGK complexes dephosphorylate 1,3BPG - Caenorhabditis elegans [Reaction:R-DME-71850] PGK complexes dephosphorylate 1,3BPG - Drosophila melanogaster [Reaction:R-GGA-71850] PGK complexes dephosphorylate 1,3BPG - Gallus gallus [Reaction:R-XTR-71850] PGK complexes dephosphorylate 1,3BPG - Xenopus tropicalis [Reaction:R-DRE-71850] PGK complexes dephosphorylate 1,3BPG - Danio rerio [Reaction:R-SSC-71850] PGK complexes dephosphorylate 1,3BPG - Sus scrofa [Reaction:R-BTA-71850] PGK complexes dephosphorylate 1,3BPG - Bos taurus [Reaction:R-CFA-71850] PGK complexes dephosphorylate 1,3BPG - Canis familiaris [Reaction:R-RNO-71850] PGK complexes dephosphorylate 1,3BPG - Rattus norvegicus [Reaction:R-MMU-71850] PGK complexes dephosphorylate 1,3BPG - Mus musculus
output	[SimpleEntity:R-ALL-29728] 3PG [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
precedingEvent	[Reaction:R-HSA-70449] GADPH tetramer dehydrogenates GA3P - Homo sapiens
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-70486] PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6809181] Jassal, Bijay, 2015-11-09
revised	[InstanceEdit:450685] D'Eustachio, P, 2009-12-16 [InstanceEdit:6809179] D'Eustachio, Peter, 2015-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71850
summation	[Summation:71784] Cytosolic phosphoglycerate kinase (PGK) catalyzes the reacti...
updateTrackers	[UpdateTracker:9791238] Update Tracker - [Reaction:71850] 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792219] Update Tracker - [Reaction:71850] 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP - v22:[modifyText] [UpdateTracker:9784022] Update Tracker - [Reaction:71850] 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP - v55:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791238] Update Tracker - [Reaction:71850] 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792219] Update Tracker - [Reaction:71850] 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP - v22:[modifyText] [UpdateTracker:9784022] Update Tracker - [Reaction:71850] 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP - v55:[addLiteratureReference, modifyText]
(replacementInstances)	[Deleted:450680] Deletion of instance: 70105
(hasEvent)	[Pathway:R-HSA-70171] Glycolysis
(precedingEvent)	[Reaction:R-HSA-71654] PGAM dimers isomerise 3PG to 2PG

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