Reactome | PGK complexes dephosphorylate 1,3BPG

PGK complexes dephosphorylate 1,3BPG

Stable Identifier

R-HSA-71850

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP, 1,3-Bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP

ReviewStatus

5/5

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Cytosolic phosphoglycerate kinase (PGK) catalyzes the reaction of ADP and 1,3-bisphosphoglycerate (1,3BPG) to form D glyceraldehyde 3-phosphate (3PG) and ATP. The active form of the enzyme is a monomer and requires Mg++ (Yoshida and Watanabe 1972; Huang et al. 1980a,b). This is the first substrate level phosphorylation reaction in glycolysis. Two PGK isoforms are known: PGK1 is widely expressed in the body while PGK2 (Chen et al. 1976; McCarrey & Thomas 1987) appears to be confined to sperm cells.

Literature References

PubMed ID	Title	Journal	Year
7391027	Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence. Huang, IY, Welch, CD, Yoshida, A	J Biol Chem	1980
1278465	Characterization of phosphoglycerate kinase from human spermatozoa Chen, SH, Donahue, RP, Scott, CR	Fertil. Steril.	1976
5009693	Human phosphoglycerate kinase. I. Crystallization and characterization of normal enzyme Yoshida, A, Watanabe, S	J Biol Chem	1972
6771269	Complete amino acid sequence of human phosphoglycerate kinase. Isolation and amino acid sequence of tryptic peptides. Huang, IY, Rubinfien, E, Yoshida, A	J Biol Chem	1980
3453121	Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene McCarrey, JR, Thomas, K	Nature	1987