Reactome | PFKFKB dimer phosphorylates Fru(6)P

Schema > Reaction > Entries

PFKFKB dimer phosphorylates Fru(6)P Show undefined attributes

catalystActivity	[CatalystActivity:163768] 6-phosphofructo-2-kinase activity of PFKFB dimers [cytosol]
catalystActivityReference	[CatalystActivityReference:9643768] 6-phosphofructo-2-kinase activity of PFKFB dimers [cytosol] Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667685] RHEA:15654 [DatabaseIdentifier:9933528] RHEA:15654
dbId	71802
deleted	[Deleted:450681] Deletion of instance: 70162
displayName	PFKFKB dimer phosphorylates Fru(6)P
eventOf	[Pathway:R-HSA-9634600] Regulation of glycolysis by fructose 2,6-bisphosphate metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24888] positive regulation of glycolytic process
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29512] Fru(6)P [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200059] Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase [LiteratureReference:200057] Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines [LiteratureReference:199999] The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate [LiteratureReference:200012] Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene [LiteratureReference:450654] Hormonal regulation of hepatic gluconeogenesis and glycolysis [LiteratureReference:70163] 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PFKFKB dimer phosphorylates Fru(6)P D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP Fructose 6-phosphate and ATP react to form fructose 2,6-bisphosphate and ADP
orthologousEvent	[Reaction:R-DRE-71802] PFKFKB dimer phosphorylates Fru(6)P - Danio rerio [Reaction:R-SCE-71802] PFKFKB dimer phosphorylates Fru(6)P - Saccharomyces cerevisiae [Reaction:R-SPO-71802] PFKFKB dimer phosphorylates Fru(6)P - Schizosaccharomyces pombe [Reaction:R-DDI-71802] PFKFKB dimer phosphorylates Fru(6)P - Dictyostelium discoideum [Reaction:R-CEL-71802] PFKFKB dimer phosphorylates Fru(6)P - Caenorhabditis elegans [Reaction:R-DME-71802] PFKFKB dimer phosphorylates Fru(6)P - Drosophila melanogaster [Reaction:R-GGA-71802] PFKFKB dimer phosphorylates Fru(6)P - Gallus gallus [Reaction:R-XTR-71802] PFKFKB dimer phosphorylates Fru(6)P - Xenopus tropicalis [Reaction:R-SSC-71802] PFKFKB dimer phosphorylates Fru(6)P - Sus scrofa [Reaction:R-BTA-71802] PFKFKB dimer phosphorylates Fru(6)P - Bos taurus [Reaction:R-CFA-71802] PFKFKB dimer phosphorylates Fru(6)P - Canis familiaris [Reaction:R-RNO-71802] PFKFKB dimer phosphorylates Fru(6)P - Rattus norvegicus [Reaction:R-MMU-71802] PFKFKB dimer phosphorylates Fru(6)P - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-30533] D-Fructose 2,6-bisphosphate [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-70471] GPI dimer isomerizes G6P - Homo sapiens [Reaction:R-HSA-163773] PKA tetramer:cAMP phosphorylates PF2K-Pase - Homo sapiens [Reaction:R-HSA-163750] PP2A complex dephosphorylates pPFKFB1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:R-HSA-163759] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9939470] Matthews, Lisa, 2025-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71802
summation	[Summation:178497] The 6-phosphofructo-2-kinase activity of cytosolic PFKFB (6-...
updateTrackers	[UpdateTracker:9790841] Update Tracker - [Reaction:71802] D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792215] Update Tracker - [Reaction:71802] D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP - v22:[addLiteratureReference] [UpdateTracker:9790526] Update Tracker - [Reaction:71802] D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP - v33:[removeRegulator] [UpdateTracker:9939687] Update Tracker - [Reaction:71802] PFKFKB dimer phosphorylates Fru(6)P - v92:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9790841] Update Tracker - [Reaction:71802] D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792215] Update Tracker - [Reaction:71802] D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP - v22:[addLiteratureReference] [UpdateTracker:9790526] Update Tracker - [Reaction:71802] D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP - v33:[removeRegulator] [UpdateTracker:9939687] Update Tracker - [Reaction:71802] PFKFKB dimer phosphorylates Fru(6)P - v92:[removeOutput]
(replacementInstances)	[Deleted:450681] Deletion of instance: 70162
(hasEvent)	[Pathway:R-HSA-9634600] Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

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