Reactome | PFKFKB dimer phosphorylates Fru(6)P

Schema > Reaction > Entries

PFKFKB dimer phosphorylates Fru(6)P Show undefined attributes

catalystActivity	[CatalystActivity:10449702] 6-phosphofructo-2-kinase activity of PFKFB dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10449704
displayName	PFKFKB dimer phosphorylates Fru(6)P
eventOf	[Pathway:R-SSC-9634600] Regulation of glycolysis by fructose 2,6-bisphosphate metabolism - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24888] positive regulation of glycolytic process
inferredFrom	[Reaction:R-HSA-71802] PFKFKB dimer phosphorylates Fru(6)P - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29512] Fru(6)P [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PFKFKB dimer phosphorylates Fru(6)P D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP Fructose 6-phosphate and ATP react to form fructose 2,6-bisphosphate and ADP
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-30533] D-Fructose 2,6-bisphosphate [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-SSC-70471] GPI dimer isomerizes G6P - Sus scrofa
regulatedBy	[PositiveRegulation:R-HSA-163759] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-71802
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9634600] Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
(inferredTo)	[Reaction:R-HSA-71802] PFKFKB dimer phosphorylates Fru(6)P

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