Reactome | D-Fructose 2,6-bisphosphate [cytosol]

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D-Fructose 2,6-bisphosphate [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-GGA-372425] fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate - Gallus gallus [Reaction:R-SCE-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Saccharomyces cerevisiae [Reaction:R-SPO-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Schizosaccharomyces pombe [Reaction:R-DDI-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Dictyostelium discoideum [Reaction:R-CEL-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Caenorhabditis elegans [Reaction:R-DME-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Drosophila melanogaster [Reaction:R-GGA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Gallus gallus [Reaction:R-XTR-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Xenopus tropicalis [Reaction:R-SSC-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Sus scrofa [Reaction:R-BTA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Bos taurus [Reaction:R-CFA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Canis familiaris [Reaction:R-RNO-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Rattus norvegicus [Reaction:R-MMU-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Mus musculus [Reaction:R-HSA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Homo sapiens [Reaction:R-DRE-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Danio rerio [Reaction:R-GGA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Gallus gallus [Reaction:R-XTR-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Xenopus tropicalis [Reaction:R-DRE-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Danio rerio [Reaction:R-SSC-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Sus scrofa [Reaction:R-BTA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Bos taurus [Reaction:R-CFA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Canis familiaris [Reaction:R-RNO-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Rattus norvegicus [Reaction:R-MMU-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Mus musculus [Reaction:R-HSA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Homo sapiens
crossReference	[DatabaseIdentifier:30534] COMPOUND:C00665
dbId	30533
displayName	D-Fructose 2,6-bisphosphate [cytosol]
inDisease	false
maxDepth	1
modified	[InstanceEdit:9939261] Weiser, Joel, 2025-02-21
name	D-Fructose 2,6-bisphosphate beta-D-fructofuranose 2,6-bisphosphate beta-D-fructofuranose 2,6-bisphosphate(4-)
negativelyRegulates	[NegativeRegulation:R-GGA-372393] Negative regulation by 'D-Fructose 2,6-bisphosphate [cytosol]'
positivelyRegulates	[PositiveRegulation:R-GGA-372398] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]' [PositiveRegulation:R-HSA-71506] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]' [PositiveRegulation:R-HSA-163759] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]'
producedByEvent	[Reaction:R-GGA-352908] fructose 6-phosphate + ATP => fructose 2,6-bisphosphate + ADP - Gallus gallus [Reaction:R-SCE-71802] PFKFKB dimer phosphorylates Fru(6)P - Saccharomyces cerevisiae [Reaction:R-SPO-71802] PFKFKB dimer phosphorylates Fru(6)P - Schizosaccharomyces pombe [Reaction:R-DDI-71802] PFKFKB dimer phosphorylates Fru(6)P - Dictyostelium discoideum [Reaction:R-CEL-71802] PFKFKB dimer phosphorylates Fru(6)P - Caenorhabditis elegans [Reaction:R-DME-71802] PFKFKB dimer phosphorylates Fru(6)P - Drosophila melanogaster [Reaction:R-GGA-71802] PFKFKB dimer phosphorylates Fru(6)P - Gallus gallus [Reaction:R-XTR-71802] PFKFKB dimer phosphorylates Fru(6)P - Xenopus tropicalis [Reaction:R-SSC-71802] PFKFKB dimer phosphorylates Fru(6)P - Sus scrofa [Reaction:R-BTA-71802] PFKFKB dimer phosphorylates Fru(6)P - Bos taurus [Reaction:R-CFA-71802] PFKFKB dimer phosphorylates Fru(6)P - Canis familiaris [Reaction:R-RNO-71802] PFKFKB dimer phosphorylates Fru(6)P - Rattus norvegicus [Reaction:R-MMU-71802] PFKFKB dimer phosphorylates Fru(6)P - Mus musculus [Reaction:R-HSA-71802] PFKFKB dimer phosphorylates Fru(6)P - Homo sapiens [Reaction:R-DRE-71802] PFKFKB dimer phosphorylates Fru(6)P - Danio rerio
referenceEntity	[ReferenceMolecule:chebi:58579] beta-D-fructofuranose 2,6-bisphosphate(4-) [ChEBI:58579]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-30533
updateTrackers	[UpdateTracker:9891846] Update Tracker - [SimpleEntity:30533] D-Fructose 2,6-bisphosphate [cytosol] - v52:[addName] [UpdateTracker:9939986] Update Tracker - [SimpleEntity:30533] D-Fructose 2,6-bisphosphate [cytosol] - v92:[add_removeReferenceEntity, removeName]

Referrals

(updatedInstance)	[UpdateTracker:9891846] Update Tracker - [SimpleEntity:30533] D-Fructose 2,6-bisphosphate [cytosol] - v52:[addName] [UpdateTracker:9939986] Update Tracker - [SimpleEntity:30533] D-Fructose 2,6-bisphosphate [cytosol] - v92:[add_removeReferenceEntity, removeName]
(input)	[Reaction:R-GGA-372425] fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate [Reaction:R-SCE-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-SPO-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-DDI-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-CEL-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-DME-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-GGA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-XTR-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-SSC-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-BTA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-CFA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-RNO-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-MMU-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-HSA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-DRE-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate [Reaction:R-GGA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate [Reaction:R-XTR-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate [Reaction:R-DRE-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate [Reaction:R-SSC-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate [Reaction:R-BTA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate [Reaction:R-CFA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate [Reaction:R-RNO-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate [Reaction:R-MMU-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate [Reaction:R-HSA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate
(output)	[Reaction:R-GGA-352908] fructose 6-phosphate + ATP => fructose 2,6-bisphosphate + ADP [Reaction:R-SCE-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-SPO-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-DDI-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-CEL-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-DME-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-GGA-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-XTR-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-SSC-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-BTA-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-CFA-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-RNO-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-MMU-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-HSA-71802] PFKFKB dimer phosphorylates Fru(6)P [Reaction:R-DRE-71802] PFKFKB dimer phosphorylates Fru(6)P
(regulator)	[NegativeRegulation:R-GGA-372393] Negative regulation by 'D-Fructose 2,6-bisphosphate [cytosol]' [PositiveRegulation:R-GGA-372398] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]' [PositiveRegulation:R-HSA-71506] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]' [PositiveRegulation:R-HSA-163759] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]'

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