Reactome | acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]

acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]

Stable Identifier

R-HSA-71723

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ALDH2 (aldehyde dehydrogenase) in the mitochondrial matrix catalyzes the reaction of acetaldehyde and NAD+ to form acetate and NADH + H+ (Greenfield and Pietruszko 1977; Hempel et al. 1985). The active form of the enzyme is a tetramer (Ni et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
4065146	Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. Hempel, J, Kaiser, R, Jornvall, H	Eur J Biochem	1985
10631996	Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms Ni, L, Zhou, J, Hurley, TD, Weiner, H	Protein Sci	1999
18196	Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes. Greenfield, NJ, Pietruszko, R	Biochim Biophys Acta	1977