Reactome | acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]

acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]

Stable Identifier

R-HSA-71723

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]

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ALDH2 (aldehyde dehydrogenase) in the mitochondrial matrix catalyzes the reaction of acetaldehyde and NAD+ to form acetate and NADH + H+ (Greenfield and Pietruszko 1977; Hempel et al. 1985). The active form of the enzyme is a tetramer (Ni et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10631996	Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms Ni, L, Zhou, J, Hurley, TD, Weiner, H	Protein Sci	1999
4065146	Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. Hempel, J, Kaiser, R, Jornvall, H	Eur J Biochem	1985
18196	Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes. Greenfield, NJ, Pietruszko, R	Biochim Biophys Acta	1977