Reactome | glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP

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glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP Show undefined attributes

catalystActivity	[CatalystActivity:71521] phosphorylase kinase activity of phosphorylase kinase complex (PHKM) [cytosol]
catalystActivityReference	[CatalystActivityReference:9643104] phosphorylase kinase activity of phosphorylase kinase complex (PHKM) [cytosol] Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9857128] RHEA:17990
dbId	71541
deleted	[Deleted:453301] Deletion of instance: 70172
displayName	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP
eventOf	[Pathway:R-HSA-70221] Glycogen breakdown (glycogenolysis) - Homo sapiens
followingEvent	[Reaction:R-HSA-71515] glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] - Homo sapiens [Reaction:R-HSA-453358] poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-71538] PYGM dimer, b form [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:453281] Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure [LiteratureReference:453283] Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases [LiteratureReference:453328] Correlation between subunit interactions and enzymatic activity of phosphorylase a. Method for determining equilibrium constants from initial rate measurements [LiteratureReference:453354] Enzymic conversion of phosphorylase a to phosphorylase b
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP L-seryl-(protein) + ATP => O-phospho-L-seryl-(protein) + ADP + H(+)
orthologousEvent	[Reaction:R-HSA-453337] glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP - Homo sapiens [Reaction:R-CEL-71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - Caenorhabditis elegans [Reaction:R-DME-71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - Drosophila melanogaster [Reaction:R-DRE-71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - Danio rerio [Reaction:R-BTA-71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - Bos taurus [Reaction:R-CFA-71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - Canis familiaris [Reaction:R-RNO-71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - Rattus norvegicus [Reaction:R-MMU-71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [Complex:R-HSA-71513] PYGM dimer a form [cytosol]
precedingEvent	[Reaction:R-HSA-453338] PYGM b dimer:AMP complex => PYGM dimer, b form + 2 AMP - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:R-HSA-71542] Positive regulation by 'Ca2+ [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9953436] Hill, David P, 2025-06-02
revised	[InstanceEdit:453329] D'Eustachio, P, 2010-01-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71541
summation	[Summation:178818] The cytosolic phosphorylase kinase complex catalyzes the pho...
updateTrackers	[UpdateTracker:9791094] Update Tracker - [Reaction:71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - v32:[add_removeLiteratureReference, modifyText] [UpdateTracker:9792226] Update Tracker - [Reaction:71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - v22:[addLiteratureReference] [UpdateTracker:9939708] Update Tracker - [Reaction:71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - v92:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9791094] Update Tracker - [Reaction:71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - v32:[add_removeLiteratureReference, modifyText] [UpdateTracker:9792226] Update Tracker - [Reaction:71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - v22:[addLiteratureReference] [UpdateTracker:9939708] Update Tracker - [Reaction:71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - v92:[removeOutput]
(replacementInstances)	[Deleted:453301] Deletion of instance: 70172
(hasEvent)	[Pathway:R-HSA-70221] Glycogen breakdown (glycogenolysis)
(precedingEvent)	[Reaction:R-HSA-71515] glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] [Reaction:R-HSA-453358] poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]

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