Reactome | glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP

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glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP Show undefined attributes

authored	[InstanceEdit:453329] D'Eustachio, P, 2010-01-21
catalystActivity	[CatalystActivity:71521] phosphorylase kinase activity of phosphorylase kinase complex (PHKM) [cytosol]
catalystActivityReference	[CatalystActivityReference:9643104] phosphorylase kinase activity of phosphorylase kinase complex (PHKM) [cytosol] Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:453352] D'Eustachio, P, 2010-01-21
crossReference	[DatabaseIdentifier:9857128] RHEA:17990
dbId	453337
displayName	glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP
eventOf	[Pathway:R-HSA-70221] Glycogen breakdown (glycogenolysis) - Homo sapiens
followingEvent	[Reaction:R-HSA-453358] poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] - Homo sapiens [Reaction:R-HSA-71515] glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] - Homo sapiens
inferredFrom	[Reaction:R-HSA-71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-71863] PYGB dimer b form [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:453361] The family of glycogen phosphorylases: structure and function
maxDepth	1
modified	[InstanceEdit:9953438] D'Eustachio, Peter, 2025-06-02
name	glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP L-seryl-(protein) + ATP => O-phospho-L-seryl-(protein) + ADP + H(+)
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [Complex:R-HSA-71869] PYGB dimer a form [cytosol]
precedingEvent	[Reaction:R-HSA-453346] PYGB b dimer:AMP complex => PGYB dimer, b form + 2 AMP - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:R-HSA-9034527] Positive regulation by 'Ca2+ [cytosol]'
regulationReference	[RegulationReference:9641440] Positive regulation by 'Ca2+ [cytosol]' 0121227022 Boyer, PD Phosphorylase kinase The Enzymes 3rd ed
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9953436] Hill, David P, 2025-06-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-453337
summation	[Summation:453343] The phosphorylation of glycogen phosphorylase PYGB by the wi...
updateTrackers	[UpdateTracker:9939650] Update Tracker - [Reaction:453337] glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP - v92:[removeOutput] [UpdateTracker:9779854] Update Tracker - [Reaction:453337] glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP - v64:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9939650] Update Tracker - [Reaction:453337] glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP - v92:[removeOutput] [UpdateTracker:9779854] Update Tracker - [Reaction:453337] glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP - v64:[addRegulator]
(hasEvent)	[Pathway:R-HSA-70221] Glycogen breakdown (glycogenolysis)
(precedingEvent)	[Reaction:R-HSA-453358] poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] [Reaction:R-HSA-71515] glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
(inferredTo)	[Reaction:R-HSA-71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP

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