Reactome | GSTZ1 isomerizes 4-MAA

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GSTZ1 isomerizes 4-MAA Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:71172] maleylacetoacetate isomerase activity of GSTZ1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643758] maleylacetoacetate isomerase activity of GSTZ1 dimer [cytosol] Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667822] RHEA:14818 [DatabaseIdentifier:9855284] RHEA:14818
dbId	71173
displayName	GSTZ1 isomerizes 4-MAA
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-8963684] Tyrosine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-71181] FAH cleaves 4FAA - Homo sapiens
input	[SimpleEntity:R-ALL-31135] 4MAA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:71167] Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity [LiteratureReference:9855790] Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique [LiteratureReference:9855775] Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a)
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	GSTZ1 isomerizes 4-MAA 4-maleylacetoacetate => 4-fumarylacetoacetate maleylacetoacetate => fumarylacetoacetate
orthologousEvent	[Reaction:R-RNO-71173] GSTZ1 isomerizes 4-MAA - Rattus norvegicus [Reaction:R-DDI-71173] GSTZ1 isomerizes 4-MAA - Dictyostelium discoideum [Reaction:R-CEL-71173] GSTZ1 isomerizes 4-MAA - Caenorhabditis elegans [Reaction:R-DME-71173] GSTZ1 isomerizes 4-MAA - Drosophila melanogaster [Reaction:R-GGA-71173] GSTZ1 isomerizes 4-MAA - Gallus gallus [Reaction:R-XTR-71173] GSTZ1 isomerizes 4-MAA - Xenopus tropicalis [Reaction:R-DRE-71173] GSTZ1 isomerizes 4-MAA - Danio rerio [Reaction:R-SSC-71173] GSTZ1 isomerizes 4-MAA - Sus scrofa [Reaction:R-BTA-71173] GSTZ1 isomerizes 4-MAA - Bos taurus [Reaction:R-CFA-71173] GSTZ1 isomerizes 4-MAA - Canis familiaris [Reaction:R-MMU-71173] GSTZ1 isomerizes 4-MAA - Mus musculus
output	[SimpleEntity:R-ALL-31175] 4FAA [cytosol]
precedingEvent	[Reaction:R-HSA-71164] HGD dioxygenates homogentisate - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71173
summation	[Summation:178945] Cytosolic maleylacetoacetic acid isomerase (MAAI, GSTZ1) cat...
updateTrackers	[UpdateTracker:9864340] Update Tracker - [Reaction:71173] GSTZ1 isomerizes 4-MAA - v88:[addLiteratureReference, modifyText] [UpdateTracker:9791182] Update Tracker - [Reaction:71173] maleylacetoacetate => fumarylacetoacetate - v32:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864340] Update Tracker - [Reaction:71173] GSTZ1 isomerizes 4-MAA - v88:[addLiteratureReference, modifyText] [UpdateTracker:9791182] Update Tracker - [Reaction:71173] maleylacetoacetate => fumarylacetoacetate - v32:[modifyText]
(hasEvent)	[Pathway:R-HSA-8963684] Tyrosine catabolism
(precedingEvent)	[Reaction:R-HSA-71181] FAH cleaves 4FAA