Reactome | HPD dioxygenates HPP

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HPD dioxygenates HPP Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:71162] 4-hydroxyphenylpyruvate dioxygenase activity of HPD:AscH-:Fe2+ dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643848] 4-hydroxyphenylpyruvate dioxygenase activity of HPD:AscH-:Fe2+ dimer [cytosol] Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667820] RHEA:16190 [DatabaseIdentifier:9855288] RHEA:16190
dbId	71163
displayName	HPD dioxygenates HPP
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-8963684] Tyrosine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-71164] HGD dioxygenates homogentisate - Homo sapiens
input	[SimpleEntity:R-ALL-31365] HPP [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:517439] Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III [LiteratureReference:9640424] The mechanism of enzymic formation of homogentisate from p-hydroxyphenylpyruvate [LiteratureReference:9855550] The genetic tyrosinemias [LiteratureReference:9855530] Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors [LiteratureReference:9855559] Identification of key residues determining the binding specificity of human 4-hydroxyphenylpyruvate dioxygenase [LiteratureReference:9855533] Functional role of residues involved in substrate binding of human 4-hydroxyphenylpyruvate dioxygenase [LiteratureReference:9855561] Nitisinone in the treatment of hereditary tyrosinaemia type 1 [LiteratureReference:9856172] From toxicological problem to therapeutic use: the discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	HPD dioxygenates HPP 3-(4-hydroxyphenyl)pyruvate + O2 => CO2 + homogentisate p-hydroxyphenylpyruvate + O2 => homogentisate + CO2
orthologousEvent	[Reaction:R-RNO-71163] HPD dioxygenates HPP - Rattus norvegicus [Reaction:R-DDI-71163] HPD dioxygenates HPP - Dictyostelium discoideum [Reaction:R-CEL-71163] HPD dioxygenates HPP - Caenorhabditis elegans [Reaction:R-DME-71163] HPD dioxygenates HPP - Drosophila melanogaster [Reaction:R-GGA-71163] HPD dioxygenates HPP - Gallus gallus [Reaction:R-XTR-71163] HPD dioxygenates HPP - Xenopus tropicalis [Reaction:R-DRE-71163] HPD dioxygenates HPP - Danio rerio [Reaction:R-SSC-71163] HPD dioxygenates HPP - Sus scrofa [Reaction:R-BTA-71163] HPD dioxygenates HPP - Bos taurus [Reaction:R-CFA-71163] HPD dioxygenates HPP - Canis familiaris [Reaction:R-MMU-71163] HPD dioxygenates HPP - Mus musculus
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-30337] HGTA [cytosol]
precedingEvent	[Reaction:R-HSA-71155] TAT deaminates tyrosine - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:9855551] Negative regulation by 'nitisinone:HPD dimer [cytosol]'
regulationReference	[RegulationReference:9856166] Negative regulation by 'nitisinone:HPD dimer [cytosol]' Nitisinone in the treatment of hereditary tyrosinaemia type 1
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9856173] D'Eustachio, Peter, 2023-12-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71163
summation	[Summation:179028] Cytosolic 4-hydroxyphenylpyruvate dioxygenase (HPD, HPPD) ca...
updateTrackers	[UpdateTracker:9864034] Update Tracker - [Reaction:71163] HPD dioxygenates HPP - v88:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9791237] Update Tracker - [Reaction:71163] p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 - v32:[add_removeLiteratureReference, modifyText] [UpdateTracker:9777660] Update Tracker - [Reaction:71163] p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 - v69:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864034] Update Tracker - [Reaction:71163] HPD dioxygenates HPP - v88:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9791237] Update Tracker - [Reaction:71163] p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 - v32:[add_removeLiteratureReference, modifyText] [UpdateTracker:9777660] Update Tracker - [Reaction:71163] p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 - v69:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-8963684] Tyrosine catabolism
(precedingEvent)	[Reaction:R-HSA-71164] HGD dioxygenates homogentisate

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