alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
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Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catalyzes the reversible reaction of alpha-aminoadipate and alpha-ketoglutarate to form alpha-ketoadipate and glutamate. Crystallographic studies have demonstrated that active AADAT enzyme is a homodimer with a pyridoxal phosphate moiety covalently attached to each monomer (Han et al. 2008; Rossi et al. 2008). The enzyme is inferred to be located within the mitochondrion because of a mitochondrial localization sequence motif at the aminoterminal end of the AADAT polypeptide (Goh et al. 2002).
Literature References
PubMed ID Title Journal Year
18056995 Crystal structure of human kynurenine aminotransferase II

Robinson, H, Li, J, Han, Q

J Biol Chem 2008
18056996 Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia

Montalbano, V, Garavaglia, S, Rizzi, M, Walsh, MA, Rossi, F

J Biol Chem 2008
12126930 Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).

Geraghty, MT, Salomons, GS, Schor, DS, Patel, A, Thomas, GH, Jakobs, C, Goh, DL

Mol Genet Metab 2002
Event Information
Catalyst Activity

2-aminoadipate transaminase activity of AADAT dimer [mitochondrial matrix]

Orthologous Events
Cross References
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