Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catalyzes the reversible reaction of alpha-aminoadipate and alpha-ketoglutarate to form alpha-ketoadipate and glutamate. Crystallographic studies have demonstrated that active AADAT enzyme is a homodimer with a pyridoxal phosphate moiety covalently attached to each monomer (Han et al. 2008; Rossi et al. 2008). The enzyme is inferred to be located within the mitochondrion because of a mitochondrial localization sequence motif at the aminoterminal end of the AADAT polypeptide (Goh et al. 2002).
Robinson, H, Li, J, Han, Q
Montalbano, V, Garavaglia, S, Rizzi, M, Walsh, MA, Rossi, F
Geraghty, MT, Salomons, GS, Schor, DS, Patel, A, Thomas, GH, Jakobs, C, Goh, DL
2-aminoadipate transaminase activity of AADAT dimer [mitochondrial matrix]
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