Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catalyzes the reversible reaction of alpha-aminoadipate and alpha-ketoglutarate to form alpha-ketoadipate and glutamate. Crystallographic studies have demonstrated that active AADAT enzyme is a homodimer with a pyridoxal phosphate moiety covalently attached to each monomer (Han et al. 2008; Rossi et al. 2008). The enzyme is inferred to be located within the mitochondrion because of a mitochondrial localization sequence motif at the aminoterminal end of the AADAT polypeptide (Goh et al. 2002).
Rossi, F, Garavaglia, S, Montalbano, V, Walsh, MA, Rizzi, M
Han, Q, Robinson, H, Li, J
Goh, DL, Patel, A, Thomas, GH, Salomons, GS, Schor, DS, Jakobs, C, Geraghty, MT
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