Reactome | Lipo-K259-DLAT [mitochondrial matrix]

Schema > EntityWithAccessionedSequence > Entries

Lipo-K259-DLAT [mitochondrial matrix] Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix
componentOf	[Complex:R-HSA-69971] lipo-K132,K259-DLAT trimer [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-69971] lipo-K132,K259-DLAT trimer [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-69971] lipo-K132,K259-DLAT trimer [mitochondrial matrix] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9861626] SIRT4 cleaves lipoyl from DLAT - Homo sapiens [Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT - Homo sapiens
dbId	69969
deleted	[Deleted:1169153] Deletion of instance: 69970
displayName	Lipo-K259-DLAT [mitochondrial matrix]
endCoordinate	647
hasModifiedResidue	[ModifiedResidue:1169151] N6-lipoyl-L-lysine at 259
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-69969] Lipo-K259-DLAT [mitochondrial matrix] - Mus musculus [EntityWithAccessionedSequence:R-RNO-69969] Lipo-K259-DLAT [mitochondrial matrix] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-69969] DLAT [mitochondrial matrix] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-69969] Lipo-K259-DLAT [mitochondrial matrix] - Bos taurus [EntityWithAccessionedSequence:R-SSC-69969] DLAT [mitochondrial matrix] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-69969] dlat [mitochondrial matrix] - Danio rerio [EntityWithAccessionedSequence:R-XTR-69969] dlat [mitochondrial matrix] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-69969] DLAT [mitochondrial matrix] - Gallus gallus [EntityWithAccessionedSequence:R-DME-69969] Dlat [mitochondrial matrix] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-69969] dlat-2 [mitochondrial matrix] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-69969] pdhC [mitochondrial matrix] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-69969] lat1 [mitochondrial matrix] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-69969] LAT1 [mitochondrial matrix] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-PFA-69969] Lipo-K259-DLAT [mitochondrial matrix] - Plasmodium falciparum
maxDepth	1
modified	[InstanceEdit:9861969] Stephan, Ralf, 2024-02-21
name	Lipo-K259-DLAT pyruvate dehydrogenase E2 subunit Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex ODP2_HUMAN Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor E2 PDC-E2 70 kDa mitochondrial autoantigen of primary biliary cirrhosis PBC M2 antigen complex 70 kDa subunit
producedByEvent	[Reaction:R-HSA-9858752] LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT - Homo sapiens [Reaction:R-HSA-9861616] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P10515] UniProt:P10515 DLAT
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-69969
startCoordinate	87
updateTrackers	[UpdateTracker:9870023] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v36:[addHasModifiedResidue, modifyName] [UpdateTracker:9884442] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v45:[addName] [UpdateTracker:9878584] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v44:[modifyEndCoordinate, modifyStartCoordinate] [UpdateTracker:9893023] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v54:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9870023] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v36:[addHasModifiedResidue, modifyName] [UpdateTracker:9884442] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v45:[addName] [UpdateTracker:9878584] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v44:[modifyEndCoordinate, modifyStartCoordinate] [UpdateTracker:9893023] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v54:[modifyName]
(replacementInstances)	[Deleted:1169153] Deletion of instance: 69970
(output)	[Reaction:R-HSA-9858752] LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT [Reaction:R-HSA-9861616] DLD dimer dehydrogenates dihydrolipoyl
(input)	[Reaction:R-HSA-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT
(activeUnit)	[CatalystActivity:9861662] dihydrolipoyllysine-residue acetyltransferase activity of PDH complex [mitochondrial matrix]
(hasComponent)	[Complex:R-HSA-69971] lipo-K132,K259-DLAT trimer [mitochondrial matrix]