Reactome | dlat [mitochondrial matrix]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:5460] mitochondrial matrix
componentOf	[Complex:R-DRE-69971] lipo-K132,K259-DLAT trimer [mitochondrial matrix] - Danio rerio [Complex:R-DRE-69971] lipo-K132,K259-DLAT trimer [mitochondrial matrix] - Danio rerio [Complex:R-DRE-69971] lipo-K132,K259-DLAT trimer [mitochondrial matrix] - Danio rerio
consumedByEvent	[Reaction:R-DRE-9861626] SIRT4 cleaves lipoyl from DLAT - Danio rerio [Reaction:R-DRE-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10576473
displayName	dlat [mitochondrial matrix]
endCoordinate	647
hasModifiedResidue	[ModifiedResidue:10576471] N6-lipoyl-L-lysine at 259 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-69969] Lipo-K259-DLAT [mitochondrial matrix] - Homo sapiens
maxDepth	1
name	dlat Lipo-K259-DLAT Q804C3
producedByEvent	[Reaction:R-DRE-9858752] LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT - Danio rerio [Reaction:R-DRE-9861616] DLD dimer dehydrogenates dihydrolipoyl - Danio rerio
referenceEntity	[ReferenceGeneProduct:uniprot:Q804C3] UniProt:Q804C3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:68323] Danio rerio
stId	R-DRE-69969
startCoordinate	87

(output)	[Reaction:R-DRE-9858752] LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT [Reaction:R-DRE-9861616] DLD dimer dehydrogenates dihydrolipoyl
(input)	[Reaction:R-DRE-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-DRE-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-69969] Lipo-K259-DLAT [mitochondrial matrix]
(hasComponent)	[Complex:R-DRE-69971] lipo-K132,K259-DLAT trimer [mitochondrial matrix]
(activeUnit)	[CatalystActivity:10645064] dihydrolipoyllysine-residue acetyltransferase activity of PDH complex [mitochondrial matrix]

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