Reactome | Proteolytic degradation of ubiquitinated-Cdc25A

Proteolytic degradation of ubiquitinated-Cdc25A

Stable Identifier

R-HSA-69600

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Independent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Independent DNA Damage Response (Homo sapiens)
        
        Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)

General

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Proteolytic degradation of ubiquitinated-Cdc25A

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'Ubiquitinated Phospho-Cdc25A' is present. At the end of this reaction, 1 molecule of 'Amino Acid' is present.

This reaction takes place in the 'cytosol' and is mediated by the 'endopeptidase activity' of '26S proteasome' (Bernardi et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10828887	Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation Bernardi, R, Hoffman, B, Liebermann, DA	Oncogene	2000