Reactome | RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]

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RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:6814886] DNA-directed RNA polymerase activity of RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[BlackBoxEvent:R-HSA-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Homo sapiens
created	[InstanceEdit:6814532] May, Bruce, 2015-11-27
dbId	6814534
displayName	RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]
hasComponent	[Complex:R-HSA-6810225] Initiation factors:CDK7:snRNA gene [nucleoplasm] [GenomeEncodedEntity:R-HSA-6814536] pre-snRNA [nucleoplasm] [Complex:R-HSA-6814533] RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Mus musculus [Complex:R-RNO-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Canis familiaris [Complex:R-BTA-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Bos taurus [Complex:R-SSC-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Sus scrofa [Complex:R-DRE-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Danio rerio [Complex:R-XTR-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Gallus gallus [Complex:R-DME-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] - Dictyostelium discoideum
isChimeric	false
isRequired	[Requirement:9685236] Requirement by 'RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]' [Requirement:9685235] Requirement by 'RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]'
literatureReference	[LiteratureReference:6814871] Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B [LiteratureReference:6814866] RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation [LiteratureReference:6810207] Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes [LiteratureReference:6814900] The Integrator complex controls the termination of transcription at diverse classes of gene targets [LiteratureReference:6807404] The little elongation complex functions at initiation and elongation phases of snRNA gene transcription
maxDepth	6
modified	[InstanceEdit:6814922] May, Bruce, 2015-11-29
name	RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:Pre-snRNA:RNU1-1,RNU2-1 gene:TBP:TFIIB:TFIIA:TFIIF:snTAFc:CDK7:SNAPc:POU2F1:ZNF143
positivelyRegulates	[Requirement:9685236] Requirement by 'RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]' [Requirement:9685235] Requirement by 'RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-HSA-6814549] Pre-snRNA transcript initiation, Integrator binding, LEC binding - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-6814534

Referrals

(regulator)	[Requirement:9685236] Requirement by 'RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]' [Requirement:9685235] Requirement by 'RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]'
(input)	[BlackBoxEvent:R-HSA-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine
(physicalEntity)	[CatalystActivity:6814886] DNA-directed RNA polymerase activity of RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]
(output)	[BlackBoxEvent:R-HSA-6814549] Pre-snRNA transcript initiation, Integrator binding, LEC binding

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