Reactome | Pre-snRNA is elongated and capped with 7-methylguanosine

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Pre-snRNA is elongated and capped with 7-methylguanosine Show undefined attributes

authored	[InstanceEdit:6814548] May, Bruce, 2015-11-21
catalystActivity	[CatalystActivity:6814886] DNA-directed RNA polymerase activity of RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6814552] May, Bruce, 2015-11-27
dbId	6814559
displayName	Pre-snRNA is elongated and capped with 7-methylguanosine
edited	[InstanceEdit:6814548] May, Bruce, 2015-11-21
eventOf	[Pathway:R-HSA-6807505] RNA polymerase II transcribes snRNA genes - Homo sapiens
followingEvent	[Reaction:R-HSA-6814885] CBCAP complex binds 7-methylguanosine cap of snRNA - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-29470] CTP [nucleoplasm] [SimpleEntity:R-ALL-113571] GTP [nucleoplasm] [Complex:R-HSA-6814534] RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] [SimpleEntity:R-ALL-113562] UTP [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6810207] Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes [LiteratureReference:6814871] Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B [LiteratureReference:6814866] RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation [LiteratureReference:197129] Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding [LiteratureReference:6814904] 5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Pre-snRNA is elongated and capped with 7-methylguanosine
orthologousEvent	[BlackBoxEvent:R-DDI-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Dictyostelium discoideum [BlackBoxEvent:R-CEL-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Caenorhabditis elegans [BlackBoxEvent:R-DME-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Drosophila melanogaster [BlackBoxEvent:R-GGA-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Gallus gallus [BlackBoxEvent:R-XTR-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Xenopus tropicalis [BlackBoxEvent:R-DRE-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Danio rerio [BlackBoxEvent:R-SSC-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Sus scrofa [BlackBoxEvent:R-BTA-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Bos taurus [BlackBoxEvent:R-CFA-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Canis familiaris [BlackBoxEvent:R-RNO-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Rattus norvegicus [BlackBoxEvent:R-MMU-6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - Mus musculus
output	[Complex:R-HSA-6814537] RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-6814549] Pre-snRNA transcript initiation, Integrator binding, LEC binding - Homo sapiens
regulatedBy	[Requirement:9685235] Requirement by 'RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]' [Requirement:9685236] Requirement by 'RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]'
regulationReference	[RegulationReference:9685238] Requirement by 'RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]' Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8858395] Hernandez, Nouria, 2016-02-19
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6814559
summation	[Summation:6814440] A 7-methylguanosine triphosphate group is added to the 5' en...
updateTrackers	[UpdateTracker:9776931] Update Tracker - [BlackBoxEvent:6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - v73:[addRegulator, removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9776931] Update Tracker - [BlackBoxEvent:6814559] Pre-snRNA is elongated and capped with 7-methylguanosine - v73:[addRegulator, removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-6807505] RNA polymerase II transcribes snRNA genes
(precedingEvent)	[Reaction:R-HSA-6814885] CBCAP complex binds 7-methylguanosine cap of snRNA

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